Zyxin is upregulated in the nucleus by thymosin β4 in SiHa cells

Hye Sung Moon; Sharona Even-Ram; Hynda K. Kleinman; Hee Jae Cha

doi:10.1016/j.yexcr.2006.07.021

Zyxin is upregulated in the nucleus by thymosin β4 in SiHa cells

Hye Sung Moon, Sharona Even-Ram, Hynda K. Kleinman, Hee Jae Cha

Department of Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Thymosin β4 is a 43-amino acid actin-binding protein that promotes cell migration and is important in angiogenesis, wound healing, and tumor metastasis. We searched for genes upregulated by thymosin β4 and identified zyxin as increased in SiHa cells in the presence of exogenously added thymosin β4 and when thymosin β4 is overexpressed using adenoviral vectors. Both zyxin and thymosin β4 show increased localization in the nucleus. We conclude that thymosin β4 may exert some of its migration promoting activity via increased zyxin expression.

Original language	English
Pages (from-to)	3425-3431
Number of pages	7
Journal	Experimental Cell Research
Volume	312
Issue number	17
DOIs	https://doi.org/10.1016/j.yexcr.2006.07.021
State	Published - 15 Oct 2006

Keywords

Actin
Focal adhesions
Migration
Nucleus
Thymosin β4
Zyxin

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10.1016/j.yexcr.2006.07.021

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title = "Zyxin is upregulated in the nucleus by thymosin β4 in SiHa cells",

abstract = "Thymosin β4 is a 43-amino acid actin-binding protein that promotes cell migration and is important in angiogenesis, wound healing, and tumor metastasis. We searched for genes upregulated by thymosin β4 and identified zyxin as increased in SiHa cells in the presence of exogenously added thymosin β4 and when thymosin β4 is overexpressed using adenoviral vectors. Both zyxin and thymosin β4 show increased localization in the nucleus. We conclude that thymosin β4 may exert some of its migration promoting activity via increased zyxin expression.",

keywords = "Actin, Focal adhesions, Migration, Nucleus, Thymosin β4, Zyxin",

author = "Moon, {Hye Sung} and Sharona Even-Ram and Kleinman, {Hynda K.} and Cha, {Hee Jae}",

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T1 - Zyxin is upregulated in the nucleus by thymosin β4 in SiHa cells

AU - Moon, Hye Sung

AU - Even-Ram, Sharona

AU - Kleinman, Hynda K.

AU - Cha, Hee Jae

PY - 2006/10/15

Y1 - 2006/10/15

N2 - Thymosin β4 is a 43-amino acid actin-binding protein that promotes cell migration and is important in angiogenesis, wound healing, and tumor metastasis. We searched for genes upregulated by thymosin β4 and identified zyxin as increased in SiHa cells in the presence of exogenously added thymosin β4 and when thymosin β4 is overexpressed using adenoviral vectors. Both zyxin and thymosin β4 show increased localization in the nucleus. We conclude that thymosin β4 may exert some of its migration promoting activity via increased zyxin expression.

AB - Thymosin β4 is a 43-amino acid actin-binding protein that promotes cell migration and is important in angiogenesis, wound healing, and tumor metastasis. We searched for genes upregulated by thymosin β4 and identified zyxin as increased in SiHa cells in the presence of exogenously added thymosin β4 and when thymosin β4 is overexpressed using adenoviral vectors. Both zyxin and thymosin β4 show increased localization in the nucleus. We conclude that thymosin β4 may exert some of its migration promoting activity via increased zyxin expression.

KW - Actin

KW - Focal adhesions

KW - Migration

KW - Nucleus

KW - Thymosin β4

KW - Zyxin

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DO - 10.1016/j.yexcr.2006.07.021

M3 - Article

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AN - SCOPUS:33748626907

SN - 0014-4827

VL - 312

SP - 3425

EP - 3431

JO - Experimental Cell Research

JF - Experimental Cell Research

IS - 17

ER -

Zyxin is upregulated in the nucleus by thymosin β4 in SiHa cells

Abstract

Keywords

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