Zn2+ enhances the intrinsic bursting activity of a rat thalamic relay neuron

Jihyun Noh; Hee joo Choi; Jun mo Chung

doi:10.1016/j.neures.2010.01.008

Zn²⁺ enhances the intrinsic bursting activity of a rat thalamic relay neuron

Jihyun Noh, Hee joo Choi, Jun mo Chung

Department of Life Science

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Although zinc ion (Zn²⁺) reduced the low-threshold T-type Ca²⁺ current of a rat thalamic relay neuron (TRN), we observed that Zn²⁺ increased a bursting activity of TRN by altering the generation and maintenance of low-threshold spike (LTS). Interestingly and importantly, Zn²⁺ shifted dramatically the voltage-dependence of both steady-state inactivation and activation of the transient A-type K⁺ current (I_A) to a depolarizing direction. As I_A is one of the main factors in shaping thalamic LTS, such alterations of gating properties of I_A would contribute to the enhancement of TRN excitability under Zn²⁺.

Original language	English
Pages (from-to)	95-97
Number of pages	3
Journal	Neuroscience Research
Volume	67
Issue number	1
DOIs	https://doi.org/10.1016/j.neures.2010.01.008
State	Published - May 2010

Bibliographical note

Funding Information:
This study was supported by Systems Biology Infrastructure Establishment Grant from GIST and a Special Grant from EWU to JMC; Noh, EWU RP-Grant 2009 recipient.

Keywords

A-channel
Electrophysiology
Epithalamus
Gating
Metals

Access to Document

10.1016/j.neures.2010.01.008

Cite this

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title = "Zn2+ enhances the intrinsic bursting activity of a rat thalamic relay neuron",

abstract = "Although zinc ion (Zn2+) reduced the low-threshold T-type Ca2+ current of a rat thalamic relay neuron (TRN), we observed that Zn2+ increased a bursting activity of TRN by altering the generation and maintenance of low-threshold spike (LTS). Interestingly and importantly, Zn2+ shifted dramatically the voltage-dependence of both steady-state inactivation and activation of the transient A-type K+ current (IA) to a depolarizing direction. As IA is one of the main factors in shaping thalamic LTS, such alterations of gating properties of IA would contribute to the enhancement of TRN excitability under Zn2+.",

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AU - Choi, Hee joo

AU - Chung, Jun mo

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AB - Although zinc ion (Zn2+) reduced the low-threshold T-type Ca2+ current of a rat thalamic relay neuron (TRN), we observed that Zn2+ increased a bursting activity of TRN by altering the generation and maintenance of low-threshold spike (LTS). Interestingly and importantly, Zn2+ shifted dramatically the voltage-dependence of both steady-state inactivation and activation of the transient A-type K+ current (IA) to a depolarizing direction. As IA is one of the main factors in shaping thalamic LTS, such alterations of gating properties of IA would contribute to the enhancement of TRN excitability under Zn2+.

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