Zn2+ enhances the intrinsic bursting activity of a rat thalamic relay neuron

Jihyun Noh, Hee joo Choi, Jun mo Chung

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Although zinc ion (Zn2+) reduced the low-threshold T-type Ca2+ current of a rat thalamic relay neuron (TRN), we observed that Zn2+ increased a bursting activity of TRN by altering the generation and maintenance of low-threshold spike (LTS). Interestingly and importantly, Zn2+ shifted dramatically the voltage-dependence of both steady-state inactivation and activation of the transient A-type K+ current (IA) to a depolarizing direction. As IA is one of the main factors in shaping thalamic LTS, such alterations of gating properties of IA would contribute to the enhancement of TRN excitability under Zn2+.

Original languageEnglish
Pages (from-to)95-97
Number of pages3
JournalNeuroscience Research
Volume67
Issue number1
DOIs
StatePublished - May 2010

Keywords

  • A-channel
  • Electrophysiology
  • Epithalamus
  • Gating
  • Metals

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