Zinc reduces low-threshold Ca2+ currents of rat thalamic relay neurons

Ji Hyun Noh, Jun Mo Chung

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Whole-cell voltage-clamping of thalamic relay neurons was used to examine the possibility of a Zn2+-mediated reduction of the low-threshold transient Ca2+ current (IT) of a central element in thalamocortical oscillations. We found that Zn2+ reversibly decreased IT in a concentration-dependent manner (IC50=55 μM), mainly by reducing the number of IT channels available for activation. Zn2+ did not affect the reaction kinetics, but did affect the voltage-dependence of IT channel gating. However, the apparent alterations in gating properties were not enough to account for the huge IT reduction.

Original languageEnglish
Pages (from-to)261-265
Number of pages5
JournalNeuroscience Research
Issue number2
StatePublished - 1 Oct 2003

Bibliographical note

Funding Information:
This study was supported in part by a KMST grant under the BSER Program, a KOSEF grant through the CCSR Research Fund, and BK 21 Project to JMC.


  • Channel blocker
  • Epilepsy
  • Metal
  • Noise analysis
  • Thalamus


Dive into the research topics of 'Zinc reduces low-threshold Ca2+ currents of rat thalamic relay neurons'. Together they form a unique fingerprint.

Cite this