Zinc increases the excitability of dopaminergic neurons in rat substantia nigra

Jun Mo Chung; Su Youne Chang; Yang In Kim; Hyung Chul Shin

doi:10.1016/S0304-3940(00)01120-4

Zinc increases the excitability of dopaminergic neurons in rat substantia nigra

Jun Mo Chung, Su Youne Chang, Yang In Kim, Hyung Chul Shin

Department of Life Science

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The effect of zinc ions (Zn²⁺) on the neuronal excitability of substantia nigra (SN) where the zinc level is known higher in Parkinsonian brains than that in normal brains has not yet been elucidated. We, therefore, examined the effect of Zn²⁺ on the intrinsic electrical properties of dopaminergic SN neurons, using a whole-cell recording method. Zn²⁺ hyperpolarized dopaminergic SN neurons at resting state. Also Zn²⁺ shortened the duration of evoked spikes, developed a fast afterhyperpolarization, and increased their firing frequency. Voltage-clamp studies showed that Zn²⁺ decreased 4-aminopyridine-sensitive outward currents, suggesting that a transient A-like potassium channel be one of the major targets Zn²⁺ can modulate in the SN neurons. (C) 2000 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	183-186
Number of pages	4
Journal	Neuroscience Letters
Volume	286
Issue number	3
DOIs	https://doi.org/10.1016/S0304-3940(00)01120-4
State	Published - 9 Jun 2000

Bibliographical note

Funding Information:
This study was supported in part by a grant from Hallym Academy of Sciences, a grant from Korean Ministry of Science and Technology under the Brain Science Research Program (98-BR-02–02-A-01), the KOSEF grant through the CCSR Research Fund, and Brain Korea 21 Project to J.M.C. S.Y.C. is a Lotte scholarship recipient.

Keywords

Electrophysiology
Metals
Midbrain
Parkinson's diseases
Whole cell recording

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title = "Zinc increases the excitability of dopaminergic neurons in rat substantia nigra",

abstract = "The effect of zinc ions (Zn2+) on the neuronal excitability of substantia nigra (SN) where the zinc level is known higher in Parkinsonian brains than that in normal brains has not yet been elucidated. We, therefore, examined the effect of Zn2+ on the intrinsic electrical properties of dopaminergic SN neurons, using a whole-cell recording method. Zn2+ hyperpolarized dopaminergic SN neurons at resting state. Also Zn2+ shortened the duration of evoked spikes, developed a fast afterhyperpolarization, and increased their firing frequency. Voltage-clamp studies showed that Zn2+ decreased 4-aminopyridine-sensitive outward currents, suggesting that a transient A-like potassium channel be one of the major targets Zn2+ can modulate in the SN neurons. (C) 2000 Elsevier Science Ireland Ltd.",

keywords = "Electrophysiology, Metals, Midbrain, Parkinson's diseases, Whole cell recording",

author = "Chung, {Jun Mo} and Chang, {Su Youne} and Kim, {Yang In} and Shin, {Hyung Chul}",

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AU - Chung, Jun Mo

AU - Chang, Su Youne

AU - Kim, Yang In

AU - Shin, Hyung Chul

N1 - Funding Information: This study was supported in part by a grant from Hallym Academy of Sciences, a grant from Korean Ministry of Science and Technology under the Brain Science Research Program (98-BR-02–02-A-01), the KOSEF grant through the CCSR Research Fund, and Brain Korea 21 Project to J.M.C. S.Y.C. is a Lotte scholarship recipient.

PY - 2000/6/9

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N2 - The effect of zinc ions (Zn2+) on the neuronal excitability of substantia nigra (SN) where the zinc level is known higher in Parkinsonian brains than that in normal brains has not yet been elucidated. We, therefore, examined the effect of Zn2+ on the intrinsic electrical properties of dopaminergic SN neurons, using a whole-cell recording method. Zn2+ hyperpolarized dopaminergic SN neurons at resting state. Also Zn2+ shortened the duration of evoked spikes, developed a fast afterhyperpolarization, and increased their firing frequency. Voltage-clamp studies showed that Zn2+ decreased 4-aminopyridine-sensitive outward currents, suggesting that a transient A-like potassium channel be one of the major targets Zn2+ can modulate in the SN neurons. (C) 2000 Elsevier Science Ireland Ltd.

AB - The effect of zinc ions (Zn2+) on the neuronal excitability of substantia nigra (SN) where the zinc level is known higher in Parkinsonian brains than that in normal brains has not yet been elucidated. We, therefore, examined the effect of Zn2+ on the intrinsic electrical properties of dopaminergic SN neurons, using a whole-cell recording method. Zn2+ hyperpolarized dopaminergic SN neurons at resting state. Also Zn2+ shortened the duration of evoked spikes, developed a fast afterhyperpolarization, and increased their firing frequency. Voltage-clamp studies showed that Zn2+ decreased 4-aminopyridine-sensitive outward currents, suggesting that a transient A-like potassium channel be one of the major targets Zn2+ can modulate in the SN neurons. (C) 2000 Elsevier Science Ireland Ltd.

KW - Electrophysiology

KW - Metals

KW - Midbrain

KW - Parkinson's diseases

KW - Whole cell recording

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DO - 10.1016/S0304-3940(00)01120-4

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VL - 286

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EP - 186

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

Zinc increases the excitability of dopaminergic neurons in rat substantia nigra

Abstract

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Keywords

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