Xylobiose prevents high-fat diet induced mice obesity by suppressing mesenteric fat deposition and metabolic dysregulation

Soo Min Lim, Eunju Kim, Jae Ho Shin, Pu Reum Seok, Sangwon Jung, Sang Ho Yoo, Yuri Kim

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Obesity is a public concern and is responsible for various metabolic diseases. Xylobiose (XB), an alternative sweetener, is a major component of xylo-oligosaccharide. The purpose of this study was to investigate the effects of XB on obesity and its associated metabolic changes in related organs. For these studies, mice received a 60% high-fat diet supplemented with 15% D-xylose, 10% XB, or 15% XB as part of the total sucrose content of the diet for ten weeks. Body weight, fat and liver weights, fasting blood glucose, and blood lipids levels were significantly reduced with XB supplementation. Levels of leptin and adipokine were also improved and lipogenic and adipogenic genes in mesenteric fat and liver were down-regulated with XB supplementation. Furthermore, pro-inflammatory cytokines, fatty acid uptake, lipolysis, and β-oxidation-related gene expression levels in mesenteric fat were down-regulated with XB supplementation. Thus, XB exhibited therapeutic potential for treating obesity which involved suppression of fat deposition and obesity-related metabolic disorders.

Original languageEnglish
Article number705
JournalMolecules
Volume23
Issue number3
DOIs
StatePublished - 2018

Keywords

  • Adipogenesis
  • Inflammation
  • Lipogenesis
  • Mesenteric adipose tissue
  • Obesity
  • Xylobiose

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