Abstract
Reducing the risk of dementia can halt the worldwide increase of affected people. The multifactorial and heterogeneous nature of late-onset dementia, including Alzheimer's disease (AD), indicates a potential impact of multidomain lifestyle interventions on risk reduction. The positive results of the landmark multidomain Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) support such an approach. The World-Wide FINGERS (WW-FINGERS), launched in 2017 and including over 25 countries, is the first global network of multidomain lifestyle intervention trials for dementia risk reduction and prevention. WW-FINGERS aims to adapt, test, and optimize the FINGER model to reduce risk across the spectrum of cognitive decline—from at-risk asymptomatic states to early symptomatic stages—in different geographical, cultural, and economic settings. WW-FINGERS aims to harmonize and adapt multidomain interventions across various countries and settings, to facilitate data sharing and analysis across studies, and to promote international joint initiatives to identify globally implementable and effective preventive strategies.
Original language | English |
---|---|
Pages (from-to) | 1078-1094 |
Number of pages | 17 |
Journal | Alzheimer's and Dementia |
Volume | 16 |
Issue number | 7 |
DOIs | |
State | Published - 1 Jul 2020 |
Keywords
- Alzheimer's disease
- World-Wide FINGERS
- cognitive impairment
- dementia
- lifestyle
- multidomain intervention
- prevention
- randomized controlled trial
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World-Wide FINGERS Network : A global approach to risk reduction and prevention of dementia. / Kivipelto, Miia; Mangialasche, Francesca; Snyder, Heather M. et al.
In: Alzheimer's and Dementia, Vol. 16, No. 7, 01.07.2020, p. 1078-1094.Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - World-Wide FINGERS Network
T2 - A global approach to risk reduction and prevention of dementia
AU - Kivipelto, Miia
AU - Mangialasche, Francesca
AU - Snyder, Heather M.
AU - Allegri, Ricardo
AU - Andrieu, Sandrine
AU - Arai, Hidenori
AU - Baker, Laura
AU - Belleville, Sylvie
AU - Brodaty, Henry
AU - Brucki, Sonia M.
AU - Calandri, Ismael
AU - Caramelli, Paulo
AU - Chen, Christopher
AU - Chertkow, Howard
AU - Chew, Effie
AU - Choi, Seong H.
AU - Chowdhary, Neerja
AU - Crivelli, Lucía
AU - Torre, Rafael De La
AU - Du, Yifeng
AU - Dua, Tarun
AU - Espeland, Mark
AU - Feldman, Howard H.
AU - Hartmanis, Maris
AU - Hartmann, Tobias
AU - Heffernan, Megan
AU - Henry, Christiani J.
AU - Hong, Chang H.
AU - Håkansson, Krister
AU - Iwatsubo, Takeshi
AU - Jeong, Jee H.
AU - Jimenez-Maggiora, Gustavo
AU - Koo, Edward H.
AU - Launer, Lenore J.
AU - Lehtisalo, Jenni
AU - Lopera, Francisco
AU - Martínez-Lage, Pablo
AU - Martins, Ralph
AU - Middleton, Lefkos
AU - Molinuevo, José L.
AU - Montero-Odasso, Manuel
AU - Moon, So Y.
AU - Morales-Pérez, Kristal
AU - Nitrini, Ricardo
AU - Nygaard, Haakon B.
AU - Park, Yoo K.
AU - Peltonen, Markku
AU - Qiu, Chengxuan
AU - Quiroz, Yakeel T.
AU - Raman, Rema
AU - Rao, Naren
AU - Ravindranath, Vijayalakshmi
AU - Rosenberg, Anna
AU - Sakurai, Takashi
AU - Salinas, Rosa M.
AU - Scheltens, Philip
AU - Sevlever, Gustavo
AU - Soininen, Hilkka
AU - Sosa, Ana L.
AU - Suemoto, Claudia K.
AU - Tainta-Cuezva, Mikel
AU - Velilla, Lina
AU - Wang, Yongxiang
AU - Whitmer, Rachel
AU - Xu, Xin
AU - Bain, Lisa J.
AU - Solomon, Alina
AU - Ngandu, Tiia
AU - Carrillo, Maria C.
N1 - Funding Information: Another study in Spain, the “Prevention of cognitive decline after a multimodal intervention combined with epigallocatechin gallate in carriers with subjective cognitive decline” (PENSA study: in Catalan PENSA means “think about”; ClinicalTrials.gov: NCT03978052) is an ongoing project in Barcelona, performed in collaboration with the Hospital del Mar Medical Research Institute (IMIM) and the BarcelonaBeta Brain Research Center (BBRC). PENSA will randomize 200 individuals meeting criteria of subjective cognitive decline (SCD), fulfilling four SCD plus features, including subjects older than 60 years and carriers. The project combines a multidomain lifestyle intervention including diet, physical activity, and cognitive stimulation and training and the administration as dietary supplement of the flavanol from green tea, epigallocatechin gallate (EGCG, 5 to 6 mg/kg up to 532 mg/day). The intervention will last 12 months. Participants will be randomized into one of four study arms (Table 1 ), and the primary outcome is global cognition measured with the ADCS Preclinical Alzheimer Cognitive Composite‐Plus‐exe. Secondary and exploratory outcomes include neuroimaging (structural and functional MRI); microbiota; neuroinflammation biomarkers; metabolomics; blood, brain‐derived exosomes, and CSF neuropathological biomarkers; physical activity, dietary assessments, cognitive training performance, and quality‐of‐life records. The project is primarily funded by the Alzheimer's Association, with additional support from the Spanish Ministry of Science, Innovation and Universities (Instituto Carlos III). APOE4 APOE 4 Funding Information: This work was supported by the Academy of Finland; Joint Program of Neurodegenerative Disorders—prevention (MIND‐AD) grant through the following funding organizations under the aegis of JPND— www.jpnd.eu: Finland, Suomen Akatemia (Academy of Finland, 291803); Sweden, Vetenskapsrådet (VR) (Swedish Research Council, 529‐2014‐7503) France, French National Agency for Research (ANR), ANR‐14‐JPPS‐0001‐02]; Swedish Research Council grant 2017‐06105; Juho Vainio Foundation, Finnish Medical Foundation; Finnish Social Insurance Institution; Ministry of Education and Culture Research Grant; Finnish Cultural Foundation; Knut and Alice Wallenberg Foundation Sweden; Center for Innovative Medicine (CIMED) at Karolinska Institutet Sweden; Stiftelsen Stockholms sjukhem Sweden; Konung Gustaf V:s och Drottning Victorias Frimurarstiftelse Sweden; af Jochnick Foundation Sweden; Alzheimer's Research and Prevention Foundation; the European Research Council Starting Grant (ERC‐804371), Alzheimerfonden Sweden; Region Stockholm (ALF and NSV grants), Sweden. U.S. POINTER trial is supported by the Alzheimer's Association POINTER‐19‐611541 and POINTER‐19‐612024 (PIs: Laura Baker, Mark Espeland, Miia Kivipelto, Rachel Whitmer, and ALZ PIs: Maria C. Carrillo and Heather M. Snyder), and ancillary Neuroimaging study to U.S. POINTER with National Institutes of Health (NIH) grant number R01AG062689 (PI: S Landau). Additional support was provided by the Wake Forest Alzheimer's Disease Core Center (P30AG049638‐01A1). The MYB trial is funded by a National Health and Medical Research Council (NHMRC) Boosting Dementia Research Team Grant (APP1095097). The SINGER study was supported by Centre For Healthy Ageing, National University Health System, Singapore. The J‐MINT study is supported by Japan Agency for Medical Research and Development. The Canadian Thumbs Up Platform Trial is part of the Canadian Consortium on Neurodegeneration in Aging (CCNA) Phase 2, which is funded by the Canadian Institutes of Health Research (CIHR #201901CNA‐417847‐CAN‐ABPI‐ 32054) and a consortium of partners including the Alzheimer Society of Canada. The work in India is made possible by funding from Centre for Brain Research, Bengaluru, India. The PENSA study is funded by the Alzheimer's Association (18PTC‐R‐592192) and the Instituto Carlos III (PI17/00223). MIND‐CHINA was supported by the National Key R&D Program of China from the Ministry of Science and Technology of China (grant no.: 2017YFC1310100), and additional grants were received from the Shandong Taishan Scholar Program, Shandong, China; the Sino‐Sweden joint research project grants from the National Natural Science Foundation of China (NSFC grant no.: 81861138008) and the Swedish Research Council (grants no.: 2017‐00740 and 2017‐05819); and the Joint China‐Sweden Mobility Programme grants from the National Natural Science Foundation of China NSFC (grant no.: 8191101618) and the Swedish Foundation for International Cooperation in Research and Higher Education (STINT, grant no.: CH2019‐8320). GOIZ ZAINDU project has been partially financed by the Health Department of the Basque Government (File No. 2017111120). Paulo Caramelli holds a senior research fellowship () from CNPq, Brazil. SUPERBRAIN was supported by the grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI18C0479). bolsa de produtividade em pesquisa Publisher Copyright: © 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Reducing the risk of dementia can halt the worldwide increase of affected people. The multifactorial and heterogeneous nature of late-onset dementia, including Alzheimer's disease (AD), indicates a potential impact of multidomain lifestyle interventions on risk reduction. The positive results of the landmark multidomain Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) support such an approach. The World-Wide FINGERS (WW-FINGERS), launched in 2017 and including over 25 countries, is the first global network of multidomain lifestyle intervention trials for dementia risk reduction and prevention. WW-FINGERS aims to adapt, test, and optimize the FINGER model to reduce risk across the spectrum of cognitive decline—from at-risk asymptomatic states to early symptomatic stages—in different geographical, cultural, and economic settings. WW-FINGERS aims to harmonize and adapt multidomain interventions across various countries and settings, to facilitate data sharing and analysis across studies, and to promote international joint initiatives to identify globally implementable and effective preventive strategies.
AB - Reducing the risk of dementia can halt the worldwide increase of affected people. The multifactorial and heterogeneous nature of late-onset dementia, including Alzheimer's disease (AD), indicates a potential impact of multidomain lifestyle interventions on risk reduction. The positive results of the landmark multidomain Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) support such an approach. The World-Wide FINGERS (WW-FINGERS), launched in 2017 and including over 25 countries, is the first global network of multidomain lifestyle intervention trials for dementia risk reduction and prevention. WW-FINGERS aims to adapt, test, and optimize the FINGER model to reduce risk across the spectrum of cognitive decline—from at-risk asymptomatic states to early symptomatic stages—in different geographical, cultural, and economic settings. WW-FINGERS aims to harmonize and adapt multidomain interventions across various countries and settings, to facilitate data sharing and analysis across studies, and to promote international joint initiatives to identify globally implementable and effective preventive strategies.
KW - Alzheimer's disease
KW - World-Wide FINGERS
KW - cognitive impairment
KW - dementia
KW - lifestyle
KW - multidomain intervention
KW - prevention
KW - randomized controlled trial
UR - http://www.scopus.com/inward/record.url?scp=85087445765&partnerID=8YFLogxK
U2 - 10.1002/alz.12123
DO - 10.1002/alz.12123
M3 - Article
C2 - 32627328
AN - SCOPUS:85087445765
SN - 1552-5260
VL - 16
SP - 1078
EP - 1094
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 7
ER -