WHO classification of malignant lymphomas in Korea: Report of the third nationwide study

Jin Man Kim; Young Hyeh Ko; Seung Sook Lee; Jooryung Huh; Chang Suk Kang; Chul Woo Kim; Yun Kyung Kang; Jai Hyang Go; Min Kyung Kim; Wan Seop Kim; Yoon Jung Kim; Hyun Jung Kim; Hee Kyung Kim; Jong Hee Nam; Hyung Bae Moon; Chan Kum Park; Tae In Park; Young Ha Oh; Dong Wha Lee; Jong Sil Lee; Juhie Lee; Hyekyung Lee; Sung Chul Lim; Kyu Yun Jang; Hee Kyung Chang; Yoon Kyung Jeon; Hye Ra Jung; Min Sun Cho; Hee Jeong Cha; Suk Jin Choi; Jae Ho Han; Sook Hee Hong; Insun Kim

doi:10.4132/KoreanJPathol.2011.45.3.254

WHO classification of malignant lymphomas in Korea: Report of the third nationwide study

Jin Man Kim, Young Hyeh Ko, Seung Sook Lee, Jooryung Huh, Chang Suk Kang, Chul Woo Kim, Yun Kyung Kang, Jai Hyang Go, Min Kyung Kim, Wan Seop Kim, Yoon Jung Kim, Hyun Jung Kim, Hee Kyung Kim, Jong Hee Nam, Hyung Bae Moon, Chan Kum Park, Tae In Park, Young Ha Oh, Dong Wha Lee, Jong Sil LeeJuhie Lee, Hyekyung Lee, Sung Chul Lim, Kyu Yun Jang, Hee Kyung Chang, Yoon Kyung Jeon, Hye Ra Jung, Min Sun Cho, Hee Jeong Cha, Suk Jin Choi, Jae Ho Han, Sook Hee Hong, Insun Kim

Department of Pathology

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

Background: The aim of study was to determine the relative frequency of malignant lymphoma according to World Health Organization (WHO) classification in Korea. Methods: A total of 3,998 cases diagnosed at 31 institutes between 2005 and 2006 were enrolled. Information including age, gender, pathologic diagnosis, site of involvement and immunophenotypes were obtained. Results: The relative frequency of non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) was 95.4% and 4.6%, respectively. B-cell lymphomas accounted for 77.6% of all NHL, while T/natural killer (T/NK)-cell lymphomas accounted for 22.4%. The most frequent subtypes of NHL were diffuse large B-cell lymphoma (42.7%), extranodal marginal zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue (19.0%), NK/T-cell lymphoma (6.3%) and peripheral T-cell lymphoma (PTCL), unspecified (6.3%), in decreasing order. The relative frequency of HL was nodular sclerosis (47.4%), mixed cellularity (30.6%), and nodular lymphocyte predominant (12.1%) subtypes. Compared with a previous study in 1998, increase in gastric MZBCL and nodular sclerosis HL, and slight decrease of follicular lymphoma, PTCL, and NK/T-cell lymphoma were observed. Conclusions: Korea had lower rates of HL and follicular lymphoma, and higher rates of extranodal NHL, extranodal MZBCL, and NK/T-cell lymphoma of nasal type compared with Western countries. Changes in the relative frequency of lymphoma subtypes are likely ascribed to refined diagnostic criteria and a change in national health care policy.

Original language	English
Pages (from-to)	254-260
Number of pages	7
Journal	Korean Journal of Pathology
Volume	45
Issue number	3
DOIs	https://doi.org/10.4132/KoreanJPathol.2011.45.3.254
State	Published - Jun 2011

Keywords

Korea
Lymphoma
Malignant
WHO

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10.4132/KoreanJPathol.2011.45.3.254

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Kim, J. M., Ko, Y. H., Lee, S. S., Huh, J., Kang, C. S., Kim, C. W., Kang, Y. K., Go, J. H., Kim, M. K., Kim, W. S., Kim, Y. J., Kim, H. J., Kim, H. K., Nam, J. H., Moon, H. B., Park, C. K., Park, T. I., Oh, Y. H., Lee, D. W., ... Kim, I. (2011). WHO classification of malignant lymphomas in Korea: Report of the third nationwide study. Korean Journal of Pathology, 45(3), 254-260. https://doi.org/10.4132/KoreanJPathol.2011.45.3.254

@article{93c3c6938a0342cf9bcf4bf5f3176ef9,

title = "WHO classification of malignant lymphomas in Korea: Report of the third nationwide study",

abstract = "Background: The aim of study was to determine the relative frequency of malignant lymphoma according to World Health Organization (WHO) classification in Korea. Methods: A total of 3,998 cases diagnosed at 31 institutes between 2005 and 2006 were enrolled. Information including age, gender, pathologic diagnosis, site of involvement and immunophenotypes were obtained. Results: The relative frequency of non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) was 95.4% and 4.6%, respectively. B-cell lymphomas accounted for 77.6% of all NHL, while T/natural killer (T/NK)-cell lymphomas accounted for 22.4%. The most frequent subtypes of NHL were diffuse large B-cell lymphoma (42.7%), extranodal marginal zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue (19.0%), NK/T-cell lymphoma (6.3%) and peripheral T-cell lymphoma (PTCL), unspecified (6.3%), in decreasing order. The relative frequency of HL was nodular sclerosis (47.4%), mixed cellularity (30.6%), and nodular lymphocyte predominant (12.1%) subtypes. Compared with a previous study in 1998, increase in gastric MZBCL and nodular sclerosis HL, and slight decrease of follicular lymphoma, PTCL, and NK/T-cell lymphoma were observed. Conclusions: Korea had lower rates of HL and follicular lymphoma, and higher rates of extranodal NHL, extranodal MZBCL, and NK/T-cell lymphoma of nasal type compared with Western countries. Changes in the relative frequency of lymphoma subtypes are likely ascribed to refined diagnostic criteria and a change in national health care policy.",

keywords = "Korea, Lymphoma, Malignant, WHO",

author = "Kim, {Jin Man} and Ko, {Young Hyeh} and Lee, {Seung Sook} and Jooryung Huh and Kang, {Chang Suk} and Kim, {Chul Woo} and Kang, {Yun Kyung} and Go, {Jai Hyang} and Kim, {Min Kyung} and Kim, {Wan Seop} and Kim, {Yoon Jung} and Kim, {Hyun Jung} and Kim, {Hee Kyung} and Nam, {Jong Hee} and Moon, {Hyung Bae} and Park, {Chan Kum} and Park, {Tae In} and Oh, {Young Ha} and Lee, {Dong Wha} and Lee, {Jong Sil} and Juhie Lee and Hyekyung Lee and Lim, {Sung Chul} and Jang, {Kyu Yun} and Chang, {Hee Kyung} and Jeon, {Yoon Kyung} and Jung, {Hye Ra} and Cho, {Min Sun} and Cha, {Hee Jeong} and Choi, {Suk Jin} and Han, {Jae Ho} and Hong, {Sook Hee} and Insun Kim",

year = "2011",

month = jun,

doi = "10.4132/KoreanJPathol.2011.45.3.254",

language = "English",

volume = "45",

pages = "254--260",

journal = "Korean Journal of Pathology",

issn = "1738-1843",

publisher = "Seoul National University",

number = "3",

}

Kim, JM, Ko, YH, Lee, SS, Huh, J, Kang, CS, Kim, CW, Kang, YK, Go, JH, Kim, MK, Kim, WS, Kim, YJ, Kim, HJ, Kim, HK, Nam, JH, Moon, HB, Park, CK, Park, TI, Oh, YH, Lee, DW, Lee, JS, Lee, J, Lee, H, Lim, SC, Jang, KY, Chang, HK, Jeon, YK, Jung, HR, Cho, MS, Cha, HJ, Choi, SJ, Han, JH, Hong, SH & Kim, I 2011, 'WHO classification of malignant lymphomas in Korea: Report of the third nationwide study', Korean Journal of Pathology, vol. 45, no. 3, pp. 254-260. https://doi.org/10.4132/KoreanJPathol.2011.45.3.254

TY - JOUR

T1 - WHO classification of malignant lymphomas in Korea

T2 - Report of the third nationwide study

AU - Kim, Jin Man

AU - Ko, Young Hyeh

AU - Lee, Seung Sook

AU - Huh, Jooryung

AU - Kang, Chang Suk

AU - Kim, Chul Woo

AU - Kang, Yun Kyung

AU - Go, Jai Hyang

AU - Kim, Min Kyung

AU - Kim, Wan Seop

AU - Kim, Yoon Jung

AU - Kim, Hyun Jung

AU - Kim, Hee Kyung

AU - Nam, Jong Hee

AU - Moon, Hyung Bae

AU - Park, Chan Kum

AU - Park, Tae In

AU - Oh, Young Ha

AU - Lee, Dong Wha

AU - Lee, Jong Sil

AU - Lee, Juhie

AU - Lee, Hyekyung

AU - Lim, Sung Chul

AU - Jang, Kyu Yun

AU - Chang, Hee Kyung

AU - Jeon, Yoon Kyung

AU - Jung, Hye Ra

AU - Cho, Min Sun

AU - Cha, Hee Jeong

AU - Choi, Suk Jin

AU - Han, Jae Ho

AU - Hong, Sook Hee

AU - Kim, Insun

PY - 2011/6

Y1 - 2011/6

N2 - Background: The aim of study was to determine the relative frequency of malignant lymphoma according to World Health Organization (WHO) classification in Korea. Methods: A total of 3,998 cases diagnosed at 31 institutes between 2005 and 2006 were enrolled. Information including age, gender, pathologic diagnosis, site of involvement and immunophenotypes were obtained. Results: The relative frequency of non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) was 95.4% and 4.6%, respectively. B-cell lymphomas accounted for 77.6% of all NHL, while T/natural killer (T/NK)-cell lymphomas accounted for 22.4%. The most frequent subtypes of NHL were diffuse large B-cell lymphoma (42.7%), extranodal marginal zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue (19.0%), NK/T-cell lymphoma (6.3%) and peripheral T-cell lymphoma (PTCL), unspecified (6.3%), in decreasing order. The relative frequency of HL was nodular sclerosis (47.4%), mixed cellularity (30.6%), and nodular lymphocyte predominant (12.1%) subtypes. Compared with a previous study in 1998, increase in gastric MZBCL and nodular sclerosis HL, and slight decrease of follicular lymphoma, PTCL, and NK/T-cell lymphoma were observed. Conclusions: Korea had lower rates of HL and follicular lymphoma, and higher rates of extranodal NHL, extranodal MZBCL, and NK/T-cell lymphoma of nasal type compared with Western countries. Changes in the relative frequency of lymphoma subtypes are likely ascribed to refined diagnostic criteria and a change in national health care policy.

AB - Background: The aim of study was to determine the relative frequency of malignant lymphoma according to World Health Organization (WHO) classification in Korea. Methods: A total of 3,998 cases diagnosed at 31 institutes between 2005 and 2006 were enrolled. Information including age, gender, pathologic diagnosis, site of involvement and immunophenotypes were obtained. Results: The relative frequency of non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) was 95.4% and 4.6%, respectively. B-cell lymphomas accounted for 77.6% of all NHL, while T/natural killer (T/NK)-cell lymphomas accounted for 22.4%. The most frequent subtypes of NHL were diffuse large B-cell lymphoma (42.7%), extranodal marginal zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue (19.0%), NK/T-cell lymphoma (6.3%) and peripheral T-cell lymphoma (PTCL), unspecified (6.3%), in decreasing order. The relative frequency of HL was nodular sclerosis (47.4%), mixed cellularity (30.6%), and nodular lymphocyte predominant (12.1%) subtypes. Compared with a previous study in 1998, increase in gastric MZBCL and nodular sclerosis HL, and slight decrease of follicular lymphoma, PTCL, and NK/T-cell lymphoma were observed. Conclusions: Korea had lower rates of HL and follicular lymphoma, and higher rates of extranodal NHL, extranodal MZBCL, and NK/T-cell lymphoma of nasal type compared with Western countries. Changes in the relative frequency of lymphoma subtypes are likely ascribed to refined diagnostic criteria and a change in national health care policy.

KW - Korea

KW - Lymphoma

KW - Malignant

KW - WHO

UR - http://www.scopus.com/inward/record.url?scp=80052412647&partnerID=8YFLogxK

U2 - 10.4132/KoreanJPathol.2011.45.3.254

DO - 10.4132/KoreanJPathol.2011.45.3.254

M3 - Article

AN - SCOPUS:80052412647

SN - 1738-1843

VL - 45

SP - 254

EP - 260

JO - Korean Journal of Pathology

JF - Korean Journal of Pathology

IS - 3

ER -

WHO classification of malignant lymphomas in Korea: Report of the third nationwide study

Abstract

Keywords

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