Walking motion of an overdamped active particle in a ratchet potential

Kong Ju Bock Lee, Chul Koo Kim, Myung Hoon Chung

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

An active particle can convert its internal energy into mechanical work. We study a generalized energy-depot model of an overdamped active particle in a ratchet potential. Using well-known biological parameters for kinesin-1 and modeling ATP influx as a pulsed energy supply, we apply our model to the molecular motor system. We find that our simple model can capture the essential properties of the kinesin motor such as forward stepping, stalling, backward stepping, dependence on ATP concentration, and stall force. Our model might be quite universal in the sense that it is able to describe dynamics of various types of motors as long as realistic parameters for each motor species are adopted.

Original languageEnglish
Pages (from-to)305-316
Number of pages12
JournalJournal of Biological Physics
Volume38
Issue number2
DOIs
StatePublished - Mar 2012

Keywords

  • Active particle
  • Energy depot model
  • Kinesin

Fingerprint

Dive into the research topics of 'Walking motion of an overdamped active particle in a ratchet potential'. Together they form a unique fingerprint.

Cite this