Visualization of endogenous and exogenous hydrogen peroxide using a lysosome-targetable fluorescent probe

Dabin Kim, Gyoungmi Kim, Sang Jip Nam, Jun Yin, Juyoung Yoon

Research output: Contribution to journalArticlepeer-review

84 Scopus citations

Abstract

Reactive oxygen species (ROS) play crucial roles in diverse physiological processes; therefore, the efficient detection of ROS is very crucial. In this study, we report a boronate-based hydrogen peroxide (H2O2) probe having naphthalimide fluorophore. This probe also contained a morpholine moiety as a directing group for lysosome. The recognition property indicated that the probe exhibited high selectivity towards H2O2 not only in the solution but also in the living cells. Furthermore, it was used to monitor the level of endogenous and exogenous H2O2. These results support that the probe can function as an efficient indicator to detect H2O2.

Original languageEnglish
Article number8488
JournalScientific Reports
Volume5
DOIs
StatePublished - 2015

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