Visible Light-Induced Aromatic Difluoroalkylation

Jaehun Jung, Eunjin Kim, Youngmin You, Eun Jin Cho

Research output: Contribution to journalArticlepeer-review

143 Scopus citations

Abstract

Difluoroalkylated aromatics are important structural motifs in pharmaceutical and agrochemical applications. Herein, we report their synthesis by a mild, efficient, and convenient method using visible light photoredox catalysis. A variety of unactivated aromatics were difluoroalkylated with ethyl 2-bromo-2,2-difluoroacetate (BrCF2CO2Et) in the presence of the triscyclometalated Ir complex fac-[Ir(ppy)3] under visible light irradiation at room temperature. It is shown that reaction outcomes containing the CF2CO2Et moiety can be converted to a variety of other CF2-containing aromatics, demonstrating the synthetic utility of the present method.

Original languageEnglish
Pages (from-to)2741-2748
Number of pages8
JournalAdvanced Synthesis and Catalysis
Volume356
Issue number13
DOIs
StatePublished - 1 Sep 2014

Keywords

  • aromatics
  • difluoroalkylation
  • heteroaromatics
  • iridium
  • visible light

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