Visible Light-Induced Aromatic Difluoroalkylation

Jaehun Jung, Eunjin Kim, Youngmin You, Eun Jin Cho

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152 Scopus citations


Difluoroalkylated aromatics are important structural motifs in pharmaceutical and agrochemical applications. Herein, we report their synthesis by a mild, efficient, and convenient method using visible light photoredox catalysis. A variety of unactivated aromatics were difluoroalkylated with ethyl 2-bromo-2,2-difluoroacetate (BrCF2CO2Et) in the presence of the triscyclometalated Ir complex fac-[Ir(ppy)3] under visible light irradiation at room temperature. It is shown that reaction outcomes containing the CF2CO2Et moiety can be converted to a variety of other CF2-containing aromatics, demonstrating the synthetic utility of the present method.

Original languageEnglish
Pages (from-to)2741-2748
Number of pages8
JournalAdvanced Synthesis and Catalysis
Issue number13
StatePublished - 1 Sep 2014

Bibliographical note

Publisher Copyright:
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


  • aromatics
  • difluoroalkylation
  • heteroaromatics
  • iridium
  • visible light


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