Versatile chemical derivatizations to design glycol chitosan-based drug carriers

Sung Eun Kim, Hak Jun Kim, Jin Kyu Rhee, Kyeongsoon Park

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Glycol chitosan (GC) and its derivatives have been extensively investigated as safe and effective drug delivery carriers because of their unique physiochemical and biological properties. The reactive functional groups such as the amine and hydroxyl groups on the GC backbone allow for easy chemical modification with various chemical compounds (e.g., hydrophobic molecules, crosslinkers, and acid-sensitive and labile molecules), and the versatility in chemical modifications enables production of a wide range of GC-based drug carriers. This review summarizes the versatile chemical modification methods that can be used to design GC-based drug carriers and describes their recent applications in disease therapy.

Original languageEnglish
Article number1662
Issue number10
StatePublished - Oct 2017

Bibliographical note

Publisher Copyright:
© 2017 by the authors.


  • Chemical derivatizations
  • Disease therapy
  • Drug carriers
  • Glycol chitosan
  • Nanoparticles


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