Venous thromboembolism following hip and knee replacement arthroplasty in Korea: A nationwide study based on claims registry

Sahnghoon Lee, Jee In Hwang, Yunjung Kim, Pil Whan Yoon, Jeonghoon Ahn, Jeong Joon Yoo

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28 Scopus citations


The aim of this study was to examine the incidence and trends of clinically relevant venous thromboembolism (VTE) including deep vein thrombosis (DVT) and pulmonary embolism (PE) after hip and knee replacement arthroplasty (HKRA) in Korea. Between January 1 and December 31, 2010, 22,127 hip replacement arthroplasty (HRA) patients and 52,882 knee replacement arthroplasty (KRA) patients were enrolled in the analysis using the administrative claims database of the Health Insurance Review and Assessment Service (HIRA). All available parameters including procedure history and clinically relevant VTE during the 90 days after HKRA were identified based on diagnostic and electronic data interchange (EDI) codes. The overall incidence of VTE, DVT, and PE during the 90 days was 3.9% (n = 853), 2.7% (n = 597), and 1.5% (n = 327) after HRA, while the incidence was 3.8% (n = 1,990), 3.2% (n = 1,699), and 0.7% (n = 355) after KRA. The incidence of VTE after HKRA was significantly higher in patients who had previous VTE history (odds ratio [OR], 10.8 after HRA, OR, 8.5 after KRA), chronic heart failure (2.1, 1.3), arrhythmia (1.8, 1.7), and atrial fibrillation (3.4, 2.1) than in patients who did not. The VTE incidence in patients with chemoprophylaxis was higher than that in patients without chemoprophylaxis. The incidence of VTEs revealed in this retrospective review was not low compared with the results of the studies targeting other Asian or Caucasian populations. It may warrant routine prevention including employment of chemoprophylaxis. However, the limitation of the reviewed data mandates large scale prospective investigation to affirm this observation.

Original languageEnglish
Pages (from-to)80-88
Number of pages9
JournalJournal of Korean Medical Science
Issue number1
StatePublished - 2016

Bibliographical note

Funding Information:
This study was supported by grants from the National Evidence-based Healthcare Collaborating Agency (NECA-B-12-003) and from the Seoul National University Hospital Research Fund (grant 3020130080).

Publisher Copyright:
© 2016 The Korean Academy of Medical Sciences.


  • Chemoprophylaxis
  • Hip
  • Knee
  • Korea
  • Replacement arthroplasty
  • Venous thromboembolism


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