Validation and determination of the contents of acetaldehyde and formaldehyde in foods

Hye Seung Jeong, Hyun Chung, Sang Hoon Song, Cho Il Kim, Joon Goo Lee, Young Suk Kim

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74 Scopus citations


The aim of this study was to develop an efficient quantitative method for the determination of acetaldehyde (AA) and formaldehyde (FA) contents in solid and liquid food matrices. The determination of those compounds was validated and performed using gas chromatography-mass spectrometry combined by solid phase micro-extraction after derivatization with O-(2,3,4,5,6-pentafluoro-benzyl)-hydroxylamine hydrochloride. Validation was carried out in terms of limit of detection, limit of quantitation, linearity, precision, and recovery. Then their contents were analyzed in various food samples including 15 fruits, 22 milk products, 31 alcohol-free beverages, and 13 alcoholic beverages. The highest contents of AA and FA were determined in a white wine (40,607.02 ng/g) and an instant coffee (1,522.46 ng/g), respectively.

Original languageEnglish
Pages (from-to)273-278
Number of pages6
JournalToxicological Research
Issue number3
StatePublished - 2015


  • Acetaldehyde (AA)
  • Food products
  • Formaldehyde (FA)
  • GC-MS
  • SPME
  • Validation


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