Vaginal Brenner tumor with literature review: Does this tumour originate from Walthard nests?

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Vaginal Brenner tumor is extremely rare. Only five cases have been reported in the English literature to date. Here we report a vaginal Brenner tumor in a 76-year old postmenopausal woman, who presented with a 2.5cm-sized sessile vaginal polyp. Microscopically, it showed characteristic features of Brenner tumor consisting of three components; transitional islands, glands, and dense fibrous stroma. The epithelial tumor cells were positive for GATA-3, p63 and ER, but negative for PAX 8. The origin of Brenner tumors in the vagina is unclear, but previous reports suggested of Müllerian origin. However, our case revealed that vaginal Walthard nests could be possible precursor lesions based on their immunohistochemical staining results.

Original languageEnglish
Pages (from-to)89-93
Number of pages5
JournalMalaysian Journal of Pathology
Issue number1
StatePublished - Apr 2017

Bibliographical note

Funding Information:
Conflict of interest: The authors have no potential conflicts of interest to disclose. Source of Funding: This study was supported by intramural research promotion grants from Ewha Womans University School of Medicine.

Publisher Copyright:
© 2017, Malaysian Society of Pathologists. All rights reserved.


  • Brenner tumour
  • Vagina
  • Walthard nest


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