Vaccine Strategy That Enhances the Protective Efficacy of Systemic Immunization by Establishing Lung-Resident Memory CD8 T Cells Against Influenza Infection

Hyun Jung Kong, Youngwon Choi, Eun Ah Kim, Jun Chang

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Most influenza vaccines currently in use target the highly variable hemagglutinin protein to induce neutralizing antibodies and therefore require yearly reformulation. T cell-based universal influenza vaccines focus on eliciting broadly cross-reactive T-cell responses, especially the tissue-resident memory T cell (TRM) population in the respiratory tract, providing superior protection to circulating memory T cells. This study demonstrated that intramuscular (i.m.) administration of the adenovirus-based vaccine expressing influenza virus nucleoprotein (rAd/NP) elicited weak CD8 TRM responses in the lungs and airways, and yielded poor protection against lethal influenza virus challenge. However, a novel “prime-and-deploy” strategy that combines i.m. vaccination of rAd/NP with subsequent intranasal administration of an empty adenovector induced strong NP-specific CD8+ TRM cells and provided complete protection against influenza virus challenge. Overall, our results demonstrate that this “prime-and-deploy” vaccination strategy is potentially applicable to the development of universal influenza vaccines.

Original languageEnglish
Article numbere32
JournalImmune Network
Volume23
Issue number4
DOIs
StatePublished - Aug 2023

Bibliographical note

Publisher Copyright:
© 2023. The Korean Association of Immunologists.

Keywords

  • Adenovirus vector
  • Influenza vaccine
  • Intramuscular administration
  • Intranasal administration
  • Lung CD8 T

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