@article{50407646650449d9af63582453b34e6b,
title = "Vaccination with a latch peptide provides serotypeindependent protection against group B streptococcus infection in mice",
abstract = "Streptococcus agalactiae (group B streptococcus [GBS]) is a leading cause of invasive diseases in neonates and severe infections in elderly individuals. GBS serine-rich repeat glycoprotein 1 (Srr1) acts as a critical virulence factor by facilitating GBS invasion into the central nervous system through interaction with the fbrinogen Aa chain. This study revealed that srr1 is highly conserved, with 86.7% of GBS clinical isolates expressing the protein. Vaccination of mice with different Srr1 truncated peptides revealed that only Srr1 truncates containing the latch domain protected against GBS meningiThis. Furthermore, the latch peptide alone was immunogenic and elicited protective antibodies, which efciently enhanced antibody-mediated opsonophagocytic killing of GBS by HL60 cells and provided heterogeneous protection against 4 different GBS serogroups. Taken together, these fndings indicated that the latch domain of Srr1 may constitute an effective peptide vaccine candidate for GBS.",
keywords = "Latch, Serine-rich repeat, Streptococcus agalactiae, Vaccine",
author = "Lin, {Shun Mei} and Jang, {A. Yeung} and Yong Zhi and Shuang Gao and Sangyong Lim and Lim, {Jae Hyang} and Song, {Joon Young} and Sullam, {Paul M.} and Rhee, {Joon Haeng} and Seo, {Ho Seong}",
note = "Funding Information: Financial support. This work was supported by the National Research Foundation of Korea (grant NRF-2015R1D1A1A01059338 to J. H. L. and grants NRF-2017M2A2A6A02020925 and NRF-2015M2A2A6A04044375 to H. S. S.), the Ministry of Food and Drug Administration (16172MFDS264 to J. Y. S.), the Ewha Womans University School of Medicine (intramural research promotion grants to J. H. L.), the Nuclear Research and Development Program of the Ministry of Science and Information and Communication Technology (to S.-M. L.), and the National Institutes of Health (R01A141513 to P. M. S.). Publisher Copyright: {\textcopyright} The Author(s) 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.",
year = "2018",
month = jan,
day = "1",
doi = "10.1093/infdis/jix565",
language = "English",
volume = "217",
pages = "93--102",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "1",
}