Utilization of photoinduced charge-separated state of donor-acceptor-linked molecules for regulation of cell membrane potential and ion transport

Tomohiro Numata, Tatsuya Murakami, Fumiaki Kawashima, Nobuhiro Morone, John E. Heuser, Yuta Takano, Kei Ohkubo, Shunichi Fukuzumi, Yasuo Mori, Hiroshi Imahori

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

The control of ion transport across cell membranes by light is an attractive strategy that allows targeted, fast control of precisely defined events in the biological membrane. Here we report a novel general strategy for the control of membrane potential and ion transport by using charge-separation molecules and light. Delivery of charge-separation molecules to the plasma membrane of PC12 cells by a membranous nanocarrier and subsequent light irradiation led to depolarization of the membrane potential as well as inhibition of the potassium ion flow across the membrane. Photoregulation of the cell membrane potential and ion transport by using charge-separation molecules is highly promising for control of cell functions.

Original languageEnglish
Pages (from-to)6092-6095
Number of pages4
JournalJournal of the American Chemical Society
Volume134
Issue number14
DOIs
StatePublished - 11 Apr 2012

Fingerprint

Dive into the research topics of 'Utilization of photoinduced charge-separated state of donor-acceptor-linked molecules for regulation of cell membrane potential and ion transport'. Together they form a unique fingerprint.

Cite this