Utilization of functionalized silane coatings for enhanced mechanical properties of hydroxyapatite filler

Eunhyun Ji, Young Hoon Song, Jeong Hyun Seo, Kye Il Joo

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Silane coupling agents are widely used as molecular bridges between inorganic minerals and organic materials to modify surface properties for diverse biomedical applications. In this study, we developed hydroxyapatite (HAp)-based scaffolds by fabricating the surface of HAp pellets with silane coupling agents containing methacrylate, amine, and carboxylic acid functional groups to improve their mechanical properties for use as biodegradable fillers in dental and bone regeneration applications. Surface coating with carboxylic acid-functionalized silane exhibited a substantially enhanced mechanical strength of up to 30MPa, which possibly resulted from the stable configuration of interfacial bonding via electrostatic attractive interaction in the a-planes of the HAp pellets. Furthermore, the functionalized silane-coated HAp scaffolds displayed excellent biocompatibility, which suggests that they could be utilized as bone filler composites for bone tissue engineering.

Original languageEnglish
Pages (from-to)1709-1714
Number of pages6
JournalKorean Journal of Chemical Engineering
Issue number7
StatePublished - Jul 2023

Bibliographical note

Funding Information:
This work was supported by the 2019 Yeungnam University Research Grant.

Publisher Copyright:
© 2023, The Korean Institute of Chemical Engineers.


  • Agglomeration
  • Hydroxyapatite
  • Molecular Bridge
  • Silane Coupling
  • Surface Modification


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