TY - JOUR
T1 - Use of saw palmetto (Serenoa repens) extract for benign prostatic hyperplasia
AU - Kwon, Youngjoo
N1 - Funding Information:
This study was supported by a grant from the Ottogi Foundation (16-241).
Publisher Copyright:
© 2019, The Korean Society of Food Science and Technology.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Benign prostatic hyperplasia (BPH) is a noncancerous growth of the prostate. BPH commonly occurs in elderly men. Lower urinary tract symptoms (LUTS) secondary to BPH (LUTS/BPH) have significant impacts on their health. Saw palmetto (Serenoa repens) extract (SPE) has been evaluated for its effectiveness in improvement of LUTS/BPH at preclinical and clinical levels. Potential mechanisms of actions include anti-androgenic, pro-apoptotic, and anti-inflammatory effects. However, SPE efficacy was inconsistent, at least partly due to a lack of a standardized SPE formula. A hexane extract (free fatty acids, > 80%) provided more consistent results. Free fatty acids (lauric acid) were effective in inhibition of 5α-reductase, and phytosterol (β-sitosterol) reduced prostatic inflammation. Multiple actions derived from different constituents may contribute to SPE efficacy. Evaluation of the clinical relevance of these bioactive components is required for standardization of SPE, thereby enabling consistent efficacy and recommendations for the use in the prevention and treatment of BPH.
AB - Benign prostatic hyperplasia (BPH) is a noncancerous growth of the prostate. BPH commonly occurs in elderly men. Lower urinary tract symptoms (LUTS) secondary to BPH (LUTS/BPH) have significant impacts on their health. Saw palmetto (Serenoa repens) extract (SPE) has been evaluated for its effectiveness in improvement of LUTS/BPH at preclinical and clinical levels. Potential mechanisms of actions include anti-androgenic, pro-apoptotic, and anti-inflammatory effects. However, SPE efficacy was inconsistent, at least partly due to a lack of a standardized SPE formula. A hexane extract (free fatty acids, > 80%) provided more consistent results. Free fatty acids (lauric acid) were effective in inhibition of 5α-reductase, and phytosterol (β-sitosterol) reduced prostatic inflammation. Multiple actions derived from different constituents may contribute to SPE efficacy. Evaluation of the clinical relevance of these bioactive components is required for standardization of SPE, thereby enabling consistent efficacy and recommendations for the use in the prevention and treatment of BPH.
KW - Benign prostatic hyperplasia
KW - Fatty acids
KW - Phytosterol
KW - Saw palmetto extract
KW - Standardized formula
UR - http://www.scopus.com/inward/record.url?scp=85072038690&partnerID=8YFLogxK
U2 - 10.1007/s10068-019-00605-9
DO - 10.1007/s10068-019-00605-9
M3 - Review article
AN - SCOPUS:85072038690
SN - 1226-7708
VL - 28
SP - 1599
EP - 1606
JO - Food Science and Biotechnology
JF - Food Science and Biotechnology
IS - 6
ER -