Use of autoantibodies against tumor-associated antigens as serum biomarkers for primary screening of cervical cancer

Yingji Jin, Seung Cheol Kim, Hyoung Jin Kim, Woong Ju, Yun Hwan Kim, Hong Jin Kim

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Serum autoantibodies against tumor-associated antigens (TAAs) have received much attention as potential biomarkers for early detection of cancers, since they can be detected in the early stages of cancers. Autoantibodies against Cancer Antigen 15-3 (CA15-3), carcinoembryonic antigen (CEA), Cancer Antigen 19-9 (CA19-9), c-Myc, p53, heat shock protein (Hsp)27 and Hsp70 have been suggested as potential markers for detecting several types of cancer. In the present study, the seven types of antibody listed above were evaluated for detecting cervical lesions. Enzymelinked immunosorbent assays (ELISAs) were used to measure IgG levels of the autoantibodies in women with normal cytology, cervical intraepithelial neoplasia (CIN) I, CIN II, CIN III and cervical cancer. The increases of anti-CA15-3 and anti- CEA IgG in cervical cancer were more pronounced than the increases of the other markers, and the level of anti-CA19-9 IgG in CIN III stage was higher than in normal CIN I, CIN II or cervical cancer. A combination of ELISAs detecting anti-CA15-3, anti-CEA and anti-CA19-9 IgGs was found to reliably discriminate CINs from normal and to strongly differentiate cancer from normal (90.3% of sensitivity and 82.1% of specificity). We suggest that the combination of three ELISA may be useful for detecting cervical lesions.

Original languageEnglish
Pages (from-to)105425-105439
Number of pages15
JournalOncotarget
Volume8
Issue number62
DOIs
StatePublished - 2017

Bibliographical note

Publisher Copyright:
© Jin et al.

Keywords

  • Autoantibody
  • Cervical cancer
  • Cervical intraepithelial neoplasia
  • Enzyme-linked immunosorbent assay
  • Tumor associated antigen

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