Urine Protein Levels Predict Future Development of Cerebral Infarction in Koreans

Sang Min Lee, Eunhee Ha, Jae Hong Ryoo

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Purpose: Proteinuria is a clinical sign of adverse cardiovascular outcomes, including stroke. We aimed to assess the relationship between proteinuria and the occurrence of cerebral infarction. Materials and Methods: In total, 208854 Koreans who participated in the 2009 medical examination were followed up until 2013 using the database of the National Health Insurance Service. The results of urine dipstick tests were utilized to assess proteinuria as absent, 1+, 2+, or ≥3+. The International Classification of Diseases code 163 was used to document cerebral infarction. Results: Between 2009 and 2013, 2383 cases (1.14%) of cerebral infarction occurred during 912772.9 person-years of follow-up. Hazard ratios for incident cerebral infarction increased with inceasing amounts of urine protein from 1.53 (1.23–1.90) in group 2 (1+), 1.67 (1.22–2.28) in group 3 (2+), and 2.66 (1.79–3.96) in group 4 (≥3+), compared to the reference group with little to no de-tectable urine protein (p<0.001, respectively). Conclusion: An increase in urine protein levels was significantly related to the risk of developing cerebral infarction. Our results suggest that proteinuria might be a potential risk factor for cerebral infarction and that urine dipstick test analysis may be clinically useful for predicting stroke.

Original languageEnglish
Pages (from-to)66-71
Number of pages6
JournalYonsei Medical Journal
Issue number1
StatePublished - Jan 2022

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea in 2020 (grant number: 2020R1G1A1102257).

Publisher Copyright:
© Yonsei University College of Medicine 2022.


  • Proteinuria
  • cardiovascular
  • cerebral infarction
  • cohort study
  • stroke


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