Abstract
Metabolomics is a powerful tool for the investigation of interactions between diet, nutrients, and human metabolism. Ecklonia cava is an edible brown alga that is abundantly found in Korea and Japan and contains unique polyphenols referred to as phlorotannins. However, there are few metabolomics studies related to the effects of polyphenols in humans. In this study, we performed a mass spectrometry-based metabolomics analysis of urine samples from participants with a body mass index (BMI) higher than 25 kg/m2 and lower than 30 kg/m2 to investigate the effects of the intake of seapolynol isolated from E. cava. Metabolomic profiling showed that the levels of riboflavin, urocanic acid, 5-hydroxy-6-methoxyindole glucuronide, and guanidino valeric acid were significantly increased in the seapolynol intake group compared with the placebo group. A correlation analysis was performed to identify the association between the metabolites’ levels and clinical characteristics related to body fat. Among the metabolites whose concentrations changed in the seapolynol intake group, riboflavin was associated with BMI, body weight, fat mass, and percent body fat. These findings suggest that the decreased body fat induced by the intake of seapolynol is related to an increase in the antioxidant effect of riboflavin.
Original language | English |
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Article number | 1407 |
Journal | Nutrients |
Volume | 12 |
Issue number | 5 |
DOIs | |
State | Published - May 2020 |
Bibliographical note
Funding Information:Funding: This research was supported by the Bio-synergy Research Project (NRF-2017M3A9C4065961) of the Ministry of Science, ICT, and Future Planning through the National Research Foundation and the Korea Basic Science Institute (060000).
Funding Information:
This research was supported by the Bio-synergy Research Project (NRF-2017M3A9C4065961) of the Ministry of Science, ICT, and Future Planning through the National Research Foundation and the Korea Basic Science Institute (060000).
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Keywords
- Antioxidant effect
- Ecklonia cava
- Mass spectrometry
- Metabolomics
- Seapolynol