Uric acid - A uremic toxin?

Takahiko Nakagawa, Marilda Mazzali, Duk Hee Kang, L. Gabriela Sánchez-Lozada, Jaime Herrera-Acosta, Richard J. Johnson

Research output: Contribution to journalReview articlepeer-review

66 Scopus citations


Uric acid might often be regarded as a simple marker of renal disease. Although it is well known that hyperuricemia causes gout which is associated with renal insufficiency and cardiovascular disease, one might think that it could attribute to the intrarenal urate crystal, but not to uric acid per se. In order to clarify the role of uric acid in the kidney, we hypothesized that uric acid causes renal disease. To generate mild hyperuricemia without intrarenal crystal in rats, we used low doses of an uricase inhibitor (2% oxonic acid). Hyperuricemia induced systemic hypertension, glomerular hypertrophy/ hypertension, afferent arteriolar sclerosis, and macrophage infiltration in normal rat kidney. In progressive renal disease, such as cyclosporine nephropathy and remnant kidney in rat, uric acid accelerated the progression of renal disease. Thus, we concluded that uric acid is not a simple marker, but a cause of renal disease.

Original languageEnglish
Pages (from-to)67-70
Number of pages4
JournalBlood Purification
Issue number1
StatePublished - Dec 2006


  • Endothelial dysfunction
  • Glomerular hypertension
  • Uric acid
  • Vascular smooth muscle cell


Dive into the research topics of 'Uric acid - A uremic toxin?'. Together they form a unique fingerprint.

Cite this