Ureaplasma and Prevotella colonization with Lactobacillus abundance during pregnancy facilitates term birth

Sunwha Park, Young Ah You, Young Han Kim, Eunjin Kwon, Abu Zar Ansari, Soo Min Kim, Gain Lee, Young Min Hur, Yun Ji Jung, Kwangmin Kim, Young Ju Kim

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Ureaplasma and Prevotella infections are well-known bacteria associated with preterm birth. However, with the development of metagenome sequencing techniques, it has been found that not all Ureaplasma and Prevotella colonizations cause preterm birth. The purpose of this study was to determine the association between Ureaplasma and Prevotella colonization with the induction of preterm birth even in the presence of Lactobacillus. In this matched case–control study, a total of 203 pregnant Korean women were selected and their cervicovaginal fluid samples were collected during mid-pregnancy. The microbiome profiles of the cervicovaginal fluid were analyzed using 16S rRNA gene amplification. Sequencing data were processed using QIIME1.9.1. Statistical analyses were performed using R software, and microbiome analysis was performed using the MicrobiomeAnalyst and Calypso software. A positive correlation between Ureaplasma and other genera was highly related to preterm birth, but interestingly, there was a negative correlation with Lactobacillus and term birth, with the same pattern observed with Prevotella. Ureaplasma and Prevotella colonization with Lactobacillus abundance during pregnancy facilitates term birth, although Ureaplasma and Prevotella are associated with preterm birth. Balanced colonization between Lactobacillus and Ureaplasma and Prevotella is important to prevent preterm birth.

Original languageEnglish
Article number10148
JournalScientific Reports
Volume12
Issue number1
DOIs
StatePublished - Dec 2022

Fingerprint

Dive into the research topics of 'Ureaplasma and Prevotella colonization with Lactobacillus abundance during pregnancy facilitates term birth'. Together they form a unique fingerprint.

Cite this