Unstable body mass index and progression to probable Alzheimer's disease dementia in patients with amnestic mild cognitive impairment

Byoung Seok Ye, Eun Young Jang, Seong Yoon Kim, Eun Joo Kim, Sun Ah Park, Yunhwan Lee, Chang Hyung Hong, Seong Hye Choi, Bora Yoon, Soo Jin Yoon, Hae Ri Na, Jae Hong Lee, Jee H. Jeong, Hee Jin Kim, Duk L. Na, Sang Won Seo

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Background and Objective: We investigated the influence of body mass index (BMI) status at baseline and changes in BMI over a follow-up period on the development of dementia in amnestic mild cognitive impairment (aMCI) patients. Methods: The longitudinal data of 747 aMCI patients were used to investigate the relationships among baseline BMI status, subsequent changes in BMI (median follow-up duration: 1.6 years, interquartile range: 1.0-2.3 years), and risk of progression to probable Alzheimer's disease dementia (pADD). The aMCI patients were classified into underweight, normal weight, overweight, and obese subgroups, and further categorized into increased BMI, stable BMI, and decreased BMI subgroups during follow-up using a 4% mean annual change in BMI cut-off value. Results: Compared to the normal weight group, the underweight group had a higher risk of pADD (hazard ratio [HR]: 1.89, 95% confidence interval [CI]: 1.07-3.37) while the obese group had a lower risk (HR: 0.70, 95% CI: 0.49-0.999). After controlling for baseline BMI status, the decreased BMI (HR: 2.29, 95% CI: 1.41-3.72) and increased BMI (HR: 3.96, 95% CI: 2.62-6.00) groups were at increased risk of progression to pADD. Conclusions: Our findings suggested that underweight at baseline was associated with a higher risk of progression to pADD, while obesity at baseline predicted a lower risk. Furthermore, significant changes in BMI during the follow-up period reflected an increased risk of progression to pADD, regardless of BMI status at baseline.

Original languageEnglish
Pages (from-to)483-491
Number of pages9
JournalJournal of Alzheimer's Disease
Volume49
Issue number2
DOIs
StatePublished - 9 Oct 2015

Keywords

  • Alzheimer's disease
  • amnestic mild cognitive impairment
  • body mass index
  • dementia
  • progression

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