Unearthing uric acid: An ancient factor with recently found significance in renal and cardiovascular disease

T. Nakagawa; D. H. Kang; D. Feig; L. G. Sanchez-Lozada; T. R. Srinivas; Y. Sautin; A. A. Ejaz; M. Segal; R. J. Johnson

doi:10.1038/sj.ki.5000391

Unearthing uric acid: An ancient factor with recently found significance in renal and cardiovascular disease

T. Nakagawa, D. H. Kang, D. Feig, L. G. Sanchez-Lozada, T. R. Srinivas, Y. Sautin, A. A. Ejaz, M. Segal, R. J. Johnson

Department of Internal Medicine

Research output: Contribution to journal › Short survey › peer-review

158 Scopus citations

Abstract

Uric acid is strongly associated with cardiovascular and renal disease, but is usually not considered to have a causal role. However, recent experimental, epidemiological, and clinical studies provocatively suggest that uric acid may contribute to the development of hypertension, metabolic syndrome, and kidney disease in some patients. Clinical studies are urgently needed to examine this important possibility.

Original language	English
Pages (from-to)	1722-1725
Number of pages	4
Journal	Kidney International
Volume	69
Issue number	10
DOIs	https://doi.org/10.1038/sj.ki.5000391
State	Published - May 2006

Bibliographical note

Funding Information:
Supported by NIH Grants DK-52121, HL-68607, and HL-79352. Dr Richard Johnson reports consultantships with TAP pharmaceuticals, Scios Inc., and Nephromics, Inc.

Keywords

Arteriolosclerosis
Chronic kidney disease
Hypertension
Metabolic syndrome
Transplant-associated kidney disease

Access to Document

10.1038/sj.ki.5000391

Cite this

@article{69fa35f062614171afca10f943bc186f,

title = "Unearthing uric acid: An ancient factor with recently found significance in renal and cardiovascular disease",

abstract = "Uric acid is strongly associated with cardiovascular and renal disease, but is usually not considered to have a causal role. However, recent experimental, epidemiological, and clinical studies provocatively suggest that uric acid may contribute to the development of hypertension, metabolic syndrome, and kidney disease in some patients. Clinical studies are urgently needed to examine this important possibility.",

keywords = "Arteriolosclerosis, Chronic kidney disease, Hypertension, Metabolic syndrome, Transplant-associated kidney disease",

author = "T. Nakagawa and Kang, {D. H.} and D. Feig and Sanchez-Lozada, {L. G.} and Srinivas, {T. R.} and Y. Sautin and Ejaz, {A. A.} and M. Segal and Johnson, {R. J.}",

note = "Funding Information: Supported by NIH Grants DK-52121, HL-68607, and HL-79352. Dr Richard Johnson reports consultantships with TAP pharmaceuticals, Scios Inc., and Nephromics, Inc.",

year = "2006",

month = may,

doi = "10.1038/sj.ki.5000391",

language = "English",

volume = "69",

pages = "1722--1725",

journal = "Kidney International",

issn = "0085-2538",

publisher = "Elsevier Inc.",

number = "10",

}

TY - JOUR

T1 - Unearthing uric acid

T2 - An ancient factor with recently found significance in renal and cardiovascular disease

AU - Nakagawa, T.

AU - Kang, D. H.

AU - Feig, D.

AU - Sanchez-Lozada, L. G.

AU - Srinivas, T. R.

AU - Sautin, Y.

AU - Ejaz, A. A.

AU - Segal, M.

AU - Johnson, R. J.

N1 - Funding Information: Supported by NIH Grants DK-52121, HL-68607, and HL-79352. Dr Richard Johnson reports consultantships with TAP pharmaceuticals, Scios Inc., and Nephromics, Inc.

PY - 2006/5

Y1 - 2006/5

N2 - Uric acid is strongly associated with cardiovascular and renal disease, but is usually not considered to have a causal role. However, recent experimental, epidemiological, and clinical studies provocatively suggest that uric acid may contribute to the development of hypertension, metabolic syndrome, and kidney disease in some patients. Clinical studies are urgently needed to examine this important possibility.

AB - Uric acid is strongly associated with cardiovascular and renal disease, but is usually not considered to have a causal role. However, recent experimental, epidemiological, and clinical studies provocatively suggest that uric acid may contribute to the development of hypertension, metabolic syndrome, and kidney disease in some patients. Clinical studies are urgently needed to examine this important possibility.

KW - Arteriolosclerosis

KW - Chronic kidney disease

KW - Hypertension

KW - Metabolic syndrome

KW - Transplant-associated kidney disease

UR - http://www.scopus.com/inward/record.url?scp=33646674298&partnerID=8YFLogxK

U2 - 10.1038/sj.ki.5000391

DO - 10.1038/sj.ki.5000391

M3 - Short survey

C2 - 16598194

AN - SCOPUS:33646674298

SN - 0085-2538

VL - 69

SP - 1722

EP - 1725

JO - Kidney International

JF - Kidney International

IS - 10

ER -

Unearthing uric acid: An ancient factor with recently found significance in renal and cardiovascular disease

Abstract

Bibliographical note

Keywords

Access to Document

Fingerprint

Cite this