Uric acid is strongly associated with cardiovascular and renal disease, but is usually not considered to have a causal role. However, recent experimental, epidemiological, and clinical studies provocatively suggest that uric acid may contribute to the development of hypertension, metabolic syndrome, and kidney disease in some patients. Clinical studies are urgently needed to examine this important possibility.
Bibliographical noteFunding Information:
Supported by NIH Grants DK-52121, HL-68607, and HL-79352. Dr Richard Johnson reports consultantships with TAP pharmaceuticals, Scios Inc., and Nephromics, Inc.
- Chronic kidney disease
- Metabolic syndrome
- Transplant-associated kidney disease