Unearthing uric acid: An ancient factor with recently found significance in renal and cardiovascular disease

T. Nakagawa, D. H. Kang, D. Feig, L. G. Sanchez-Lozada, T. R. Srinivas, Y. Sautin, A. A. Ejaz, M. Segal, R. J. Johnson

Research output: Contribution to journalShort surveypeer-review

157 Scopus citations

Abstract

Uric acid is strongly associated with cardiovascular and renal disease, but is usually not considered to have a causal role. However, recent experimental, epidemiological, and clinical studies provocatively suggest that uric acid may contribute to the development of hypertension, metabolic syndrome, and kidney disease in some patients. Clinical studies are urgently needed to examine this important possibility.

Original languageEnglish
Pages (from-to)1722-1725
Number of pages4
JournalKidney International
Volume69
Issue number10
DOIs
StatePublished - May 2006

Bibliographical note

Funding Information:
Supported by NIH Grants DK-52121, HL-68607, and HL-79352. Dr Richard Johnson reports consultantships with TAP pharmaceuticals, Scios Inc., and Nephromics, Inc.

Keywords

  • Arteriolosclerosis
  • Chronic kidney disease
  • Hypertension
  • Metabolic syndrome
  • Transplant-associated kidney disease

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