Ultrasound-guided percutaneous portal transplantation of peripheral blood monocytes in patients with liver cirrhosis

Su Jong Yu, Jung Hwan Yoon, Won Kim, Jeong Min Lee, Yun Bin Lee, Yuri Cho, Dong Hyeon Lee, Minjong Lee, Jeong Ju Yoo, Eun Ju Cho, Jeong Hoon Lee, Yoon Jun Kim, Chung Yong Kim

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Background/Aims: Liver transplantation offers the only definite cure for cirrhosis but lacking donors is problem. Stem cell therapy is attractive in this setting. In this study, we aimed to explore the safety and efficacy of ultrasound-guided percutaneous portal transplantation of peripheral blood monocyte cell (PBMC) in cirrhotic patients. Methods: A total of nine decompensated cirrhotic patients were randomized into three groups: group 1 (n = 3) was control group, group 2 (n = 3) received granulo-cyte-colony stimulating factor (G-CSF) mobilization for 3 days, and group 3 (n = 3) received G-CSF mobilized PBMCs by leukapheresis and PBMC transplantation through ultrasound-guided percutaneous portal vein puncture. Liver function and clinical features were evaluated. Results: At baseline, the Child-Turcotte-Pugh and the model for end-stage liver disease scores were comparable in study groups. Compared with group 1, there was a tendency to improve liver function in group 3 at 6 months after treatment. Treatment was tolerable and no complications were encountered related to the G-CSF mobilization or percutaneous portal administration of PBMCs. Imaging studies showed patent portal veins at the end of the study period. Conclusions: Autologous PBMC transplantation through ultrasound-guided percutaneous portal vein puncture could be considered as a safe alternative treatment for decompensated cirrhotic patients.

Original languageEnglish
Pages (from-to)261-268
Number of pages8
JournalKorean Journal of Internal Medicine
Volume32
Issue number2
DOIs
StatePublished - 2017

Bibliographical note

Funding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (Grant No. 20100007381) and by the Liver Research Foundation of Korea. We thank MRCC (medical research collaborating center) of Seoul National University Hospital for assistance in statistical analysis.

Publisher Copyright:
© 2017 The Korean Association of Internal Medicine.

Keywords

  • Granulocyte colony-stimulating factor
  • Leukocytes
  • Liver cirrhosis
  • Mononuclear

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