Ultrasonic modulation of neuronal activity

Seoyoung Hwang; Sang Beom Jun

doi:10.1109/ICEIC49074.2020.9051016

Ultrasonic modulation of neuronal activity

Seoyoung Hwang, Sang Beom Jun

Electronic and Electrical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Recently, ultrasound is emerging as an advantageous neuromodulation method due to its noninvasiveness and the high spatial resolution. However, the underlying mechanism have not been elucidated yet. Furthermore, the effective parameters for ultrasound neuromodulation is not well established. In this study, we aim to determine the optimized ultrasound condition using cultured neurons on microelectrode arrays. Various combination of ultrasound parameters were tested on the cultured neural cells. With 0.5 MHz center frequency ultrasound, 7.66 W/cm² spatial peak pulse average intensity, 3.83 W/cm² spatial peak temporal average acoustic intensity, 50 % duty cycle and 1 kHz pulse repetition frequency were the most effective to modulate the activity of neurons.

Original language	English
Title of host publication	2020 International Conference on Electronics, Information, and Communication, ICEIC 2020
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781728162898
DOIs	https://doi.org/10.1109/ICEIC49074.2020.9051016
State	Published - Jan 2020
Event	2020 International Conference on Electronics, Information, and Communication, ICEIC 2020 - Barcelona, Spain Duration: 19 Jan 2020 → 22 Jan 2020

Publication series

Name	2020 International Conference on Electronics, Information, and Communication, ICEIC 2020

Conference

Conference	2020 International Conference on Electronics, Information, and Communication, ICEIC 2020
Country/Territory	Spain
City	Barcelona
Period	19/01/20 → 22/01/20

Bibliographical note

Funding Information:
This study was supported by the smart IT convergence system research center funded by the ministry of education, science and technology as global frontier project (CISS-2012M3A6A6054204) and Convergent Technology R&D Program for Human Augmentation through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2019M3C1B8090805)

Publisher Copyright:
© 2020 IEEE.

Keywords

Microelectrode arrays (MEA)
Neuromodulation
Neuron
Ultrasound

Access to Document

10.1109/ICEIC49074.2020.9051016

Cite this

Hwang, S., & Jun, S. B. (2020). Ultrasonic modulation of neuronal activity. In 2020 International Conference on Electronics, Information, and Communication, ICEIC 2020 Article 9051016 (2020 International Conference on Electronics, Information, and Communication, ICEIC 2020). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ICEIC49074.2020.9051016

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abstract = "Recently, ultrasound is emerging as an advantageous neuromodulation method due to its noninvasiveness and the high spatial resolution. However, the underlying mechanism have not been elucidated yet. Furthermore, the effective parameters for ultrasound neuromodulation is not well established. In this study, we aim to determine the optimized ultrasound condition using cultured neurons on microelectrode arrays. Various combination of ultrasound parameters were tested on the cultured neural cells. With 0.5 MHz center frequency ultrasound, 7.66 W/cm2 spatial peak pulse average intensity, 3.83 W/cm2 spatial peak temporal average acoustic intensity, 50 % duty cycle and 1 kHz pulse repetition frequency were the most effective to modulate the activity of neurons.",

keywords = "Microelectrode arrays (MEA), Neuromodulation, Neuron, Ultrasound",

author = "Seoyoung Hwang and Jun, {Sang Beom}",

note = "Funding Information: This study was supported by the smart IT convergence system research center funded by the ministry of education, science and technology as global frontier project (CISS-2012M3A6A6054204) and Convergent Technology R&D Program for Human Augmentation through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2019M3C1B8090805) Publisher Copyright: {\textcopyright} 2020 IEEE.; 2020 International Conference on Electronics, Information, and Communication, ICEIC 2020 ; Conference date: 19-01-2020 Through 22-01-2020",

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Hwang, S & Jun, SB 2020, Ultrasonic modulation of neuronal activity. in 2020 International Conference on Electronics, Information, and Communication, ICEIC 2020., 9051016, 2020 International Conference on Electronics, Information, and Communication, ICEIC 2020, Institute of Electrical and Electronics Engineers Inc., 2020 International Conference on Electronics, Information, and Communication, ICEIC 2020, Barcelona, Spain, 19/01/20. https://doi.org/10.1109/ICEIC49074.2020.9051016

Ultrasonic modulation of neuronal activity. / Hwang, Seoyoung; Jun, Sang Beom.
2020 International Conference on Electronics, Information, and Communication, ICEIC 2020. Institute of Electrical and Electronics Engineers Inc., 2020. 9051016 (2020 International Conference on Electronics, Information, and Communication, ICEIC 2020).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AB - Recently, ultrasound is emerging as an advantageous neuromodulation method due to its noninvasiveness and the high spatial resolution. However, the underlying mechanism have not been elucidated yet. Furthermore, the effective parameters for ultrasound neuromodulation is not well established. In this study, we aim to determine the optimized ultrasound condition using cultured neurons on microelectrode arrays. Various combination of ultrasound parameters were tested on the cultured neural cells. With 0.5 MHz center frequency ultrasound, 7.66 W/cm2 spatial peak pulse average intensity, 3.83 W/cm2 spatial peak temporal average acoustic intensity, 50 % duty cycle and 1 kHz pulse repetition frequency were the most effective to modulate the activity of neurons.

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Ultrasonic modulation of neuronal activity

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Keywords

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