TY - GEN
T1 - Ultrasonic modulation of neuronal activity
AU - Hwang, Seoyoung
AU - Jun, Sang Beom
N1 - Funding Information:
This study was supported by the smart IT convergence system research center funded by the ministry of education, science and technology as global frontier project (CISS-2012M3A6A6054204) and Convergent Technology R&D Program for Human Augmentation through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2019M3C1B8090805)
Publisher Copyright:
© 2020 IEEE.
PY - 2020/1
Y1 - 2020/1
N2 - Recently, ultrasound is emerging as an advantageous neuromodulation method due to its noninvasiveness and the high spatial resolution. However, the underlying mechanism have not been elucidated yet. Furthermore, the effective parameters for ultrasound neuromodulation is not well established. In this study, we aim to determine the optimized ultrasound condition using cultured neurons on microelectrode arrays. Various combination of ultrasound parameters were tested on the cultured neural cells. With 0.5 MHz center frequency ultrasound, 7.66 W/cm2 spatial peak pulse average intensity, 3.83 W/cm2 spatial peak temporal average acoustic intensity, 50 % duty cycle and 1 kHz pulse repetition frequency were the most effective to modulate the activity of neurons.
AB - Recently, ultrasound is emerging as an advantageous neuromodulation method due to its noninvasiveness and the high spatial resolution. However, the underlying mechanism have not been elucidated yet. Furthermore, the effective parameters for ultrasound neuromodulation is not well established. In this study, we aim to determine the optimized ultrasound condition using cultured neurons on microelectrode arrays. Various combination of ultrasound parameters were tested on the cultured neural cells. With 0.5 MHz center frequency ultrasound, 7.66 W/cm2 spatial peak pulse average intensity, 3.83 W/cm2 spatial peak temporal average acoustic intensity, 50 % duty cycle and 1 kHz pulse repetition frequency were the most effective to modulate the activity of neurons.
KW - Microelectrode arrays (MEA)
KW - Neuromodulation
KW - Neuron
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=85083504407&partnerID=8YFLogxK
U2 - 10.1109/ICEIC49074.2020.9051016
DO - 10.1109/ICEIC49074.2020.9051016
M3 - Conference contribution
AN - SCOPUS:85083504407
T3 - 2020 International Conference on Electronics, Information, and Communication, ICEIC 2020
BT - 2020 International Conference on Electronics, Information, and Communication, ICEIC 2020
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2020 International Conference on Electronics, Information, and Communication, ICEIC 2020
Y2 - 19 January 2020 through 22 January 2020
ER -