TY - JOUR
T1 - Ultrasensitive, Selective, and Highly Stable Bioelectronic Nose That Detects the Liquid and Gaseous Cadaverine
AU - Oh, Jungkyun
AU - Yang, Heehong
AU - Jeong, Go Een
AU - Moon, Dongseok
AU - Kwon, Oh Seok
AU - Phyo, Sooyeol
AU - Lee, Jiwon
AU - Song, Hyun Seok
AU - Park, Tai Hyun
AU - Jang, Jyongsik
N1 - Publisher Copyright:
© 2019 American Chemical Society.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Field-effect transistor (FET) devices based on conductive nanomaterials have been used to develop biosensors. However, development of FET-based biosensors that allow efficient stability, especially in the gas phase, for obtaining reliable and reproducible responses remains a challenge. In this study, we developed a nanodisc (ND)-functionalized bioelectronic nose (NBN) based on a nickel (Ni)-decorated carboxylated polypyrrole nanoparticle (cPPyNP)-FET that offers the detection of liquid and gaseous cadaverine (CV). The TAAR13c, specifically binding to CV, which is an indicator of food spoilage, was successfully constructed in NDs. The NBN was fabricated by the oriented assembly of TAAR13c-embedded NDs (T13NDs) onto the transistor with Ni/cPPyNPs. The NBN showed high performance in selectivity and sensitivity for the detection of CV, with excellent stability in both aqueous and gas phases. Moreover, the NBN allowed efficient measurement of corrupted real-food samples. It demonstrates the ND-based device can allow the practical biosensor that provides high stability in the gas phase.
AB - Field-effect transistor (FET) devices based on conductive nanomaterials have been used to develop biosensors. However, development of FET-based biosensors that allow efficient stability, especially in the gas phase, for obtaining reliable and reproducible responses remains a challenge. In this study, we developed a nanodisc (ND)-functionalized bioelectronic nose (NBN) based on a nickel (Ni)-decorated carboxylated polypyrrole nanoparticle (cPPyNP)-FET that offers the detection of liquid and gaseous cadaverine (CV). The TAAR13c, specifically binding to CV, which is an indicator of food spoilage, was successfully constructed in NDs. The NBN was fabricated by the oriented assembly of TAAR13c-embedded NDs (T13NDs) onto the transistor with Ni/cPPyNPs. The NBN showed high performance in selectivity and sensitivity for the detection of CV, with excellent stability in both aqueous and gas phases. Moreover, the NBN allowed efficient measurement of corrupted real-food samples. It demonstrates the ND-based device can allow the practical biosensor that provides high stability in the gas phase.
UR - http://www.scopus.com/inward/record.url?scp=85072791403&partnerID=8YFLogxK
U2 - 10.1021/acs.analchem.9b01068
DO - 10.1021/acs.analchem.9b01068
M3 - Article
C2 - 31478373
AN - SCOPUS:85072791403
SN - 0003-2700
VL - 91
SP - 12181
EP - 12190
JO - Analytical Chemistry
JF - Analytical Chemistry
IS - 19
ER -