Ultrasensitive, Selective, and Highly Stable Bioelectronic Nose That Detects the Liquid and Gaseous Cadaverine

Jungkyun Oh, Heehong Yang, Go Een Jeong, Dongseok Moon, Oh Seok Kwon, Sooyeol Phyo, Jiwon Lee, Hyun Seok Song, Tai Hyun Park, Jyongsik Jang

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Field-effect transistor (FET) devices based on conductive nanomaterials have been used to develop biosensors. However, development of FET-based biosensors that allow efficient stability, especially in the gas phase, for obtaining reliable and reproducible responses remains a challenge. In this study, we developed a nanodisc (ND)-functionalized bioelectronic nose (NBN) based on a nickel (Ni)-decorated carboxylated polypyrrole nanoparticle (cPPyNP)-FET that offers the detection of liquid and gaseous cadaverine (CV). The TAAR13c, specifically binding to CV, which is an indicator of food spoilage, was successfully constructed in NDs. The NBN was fabricated by the oriented assembly of TAAR13c-embedded NDs (T13NDs) onto the transistor with Ni/cPPyNPs. The NBN showed high performance in selectivity and sensitivity for the detection of CV, with excellent stability in both aqueous and gas phases. Moreover, the NBN allowed efficient measurement of corrupted real-food samples. It demonstrates the ND-based device can allow the practical biosensor that provides high stability in the gas phase.

Original languageEnglish
Pages (from-to)12181-12190
Number of pages10
JournalAnalytical Chemistry
Volume91
Issue number19
DOIs
StatePublished - 1 Oct 2019

Bibliographical note

Funding Information:
This research was supported by the National Research Foundation funded by the Korean government (MSIT; NRF-2018R1A2B3004498). This study was also supported by the KIST Institutional Program (No. 2E29530), a National Research Council of Science and Technology (NST) Grant by the Korea government (MSIP; No. CRC-16-01-KRICT), the Korea Basic Science Institute (D38410), and Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry (IPET) through the Advanced Production Technology Development Program, funded by the Ministry of Agriculture, Food and Rural Affairs (MAFRA; 318104-3).

Publisher Copyright:
© 2019 American Chemical Society.

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