Ultrasensitive and Selective Field-Effect Transistor-Based Biosensor Created by Rings of MoS2 Nanopores

Heekyeong Park, Seungho Baek, Anamika Sen, Bongjin Jung, Junoh Shim, Yun Chang Park, Luke P. Lee, Young Jun Kim, Sunkook Kim

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


The ubiquitous field-effect transistor (FET) is widely used in modern digital integrated circuits, computers, communications, sensors, and other applications. However, reliable biological FET (bio-FET) is not available in real life due to the rigorous requirement for highly sensitive and selective bio-FET fabrication, which remains a challenging task. Here, we report an ultrasensitive and selective bio-FET created by the nanorings of molybdenum disulfide (MoS2) nanopores inspired by nuclear pore complexes. We characterize the nanoring of MoS2 nanopores by scanning transmission electron microscopy, Raman, and X-ray photoelectron spectroscopy spectra. After fabricating MoS2 nanopore rings-based bio-FET, we confirm edge-selective functionalization by the gold nanoparticle tethering test and the change of electrical signal of the bio-FET. Ultrahigh sensitivity of the MoS2 nanopore edge rings-based bio-FET (limit of detection of 1 ag/mL) and high selectivity are accomplished by effective coupling of the aptamers on the nanorings of the MoS2 nanopore edge for cortisol detection. We believe that MoS2 nanopore edge rings-based bio-FET would provide platforms for everyday biosensors with ultrahigh sensitivity and selectivity.

Original languageEnglish
Pages (from-to)1826-1835
Number of pages10
JournalACS Nano
Issue number2
StatePublished - 22 Feb 2022

Bibliographical note

Publisher Copyright:
© 2021 American Chemical Society


  • MoS bio-FET
  • edge engineering
  • edge functionalization
  • nanopatterning
  • ultrasensitive biosensor


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