Two new secondary metabolites, saccharochlorines A and B, from a marine bacterium Saccharomonospora sp. KCTC-19160

Tu Cam Le; Nikita Katila; Songhee Park; Jihye Lee; Inho Yang; Hyukjae Choi; Dong Young Choi; Sang Jip Nam

doi:10.1016/j.bmcl.2020.127145

Two new secondary metabolites, saccharochlorines A and B, from a marine bacterium Saccharomonospora sp. KCTC-19160

Tu Cam Le, Nikita Katila, Songhee Park, Jihye Lee, Inho Yang, Hyukjae Choi, Dong Young Choi, Sang Jip Nam

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Two new chlorinated secondary metabolites, saccharochlorines A and B (1 and 2), were isolated from the saline cultivation of a marine-derived bacterium Saccharomonospora sp. (KCTC-19160). The chemical structures of the saccharochlorines were elucidated by 2D NMR and MS spectroscopic data. Saccharochlorines A and B (1 and 2) exhibit weak inhibition of β-secretase (BACE1) in biochemical inhibitory assay, but they induced the release of Aβ (1–40) and Aβ (1–42) in H4-APP neuroglial cells. This discrepancy might be derived from the differences between the cellular and sub-cellular environments or the epigenetic stimulation of BACE1 expression.

Original language	English
Article number	127145
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	30
Issue number	11
DOIs	https://doi.org/10.1016/j.bmcl.2020.127145
State	Published - 1 Jun 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Ltd

Keywords

Chlorinated secondary metabolites
Marine natural products
Saccharomonospora sp.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2020.127145

Cite this

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title = "Two new secondary metabolites, saccharochlorines A and B, from a marine bacterium Saccharomonospora sp. KCTC-19160",

abstract = "Two new chlorinated secondary metabolites, saccharochlorines A and B (1 and 2), were isolated from the saline cultivation of a marine-derived bacterium Saccharomonospora sp. (KCTC-19160). The chemical structures of the saccharochlorines were elucidated by 2D NMR and MS spectroscopic data. Saccharochlorines A and B (1 and 2) exhibit weak inhibition of β-secretase (BACE1) in biochemical inhibitory assay, but they induced the release of Aβ (1–40) and Aβ (1–42) in H4-APP neuroglial cells. This discrepancy might be derived from the differences between the cellular and sub-cellular environments or the epigenetic stimulation of BACE1 expression.",

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AU - Le, Tu Cam

AU - Katila, Nikita

AU - Park, Songhee

AU - Lee, Jihye

AU - Yang, Inho

AU - Choi, Hyukjae

AU - Choi, Dong Young

AU - Nam, Sang Jip

PY - 2020/6/1

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KW - Chlorinated secondary metabolites

KW - Marine natural products

KW - Saccharomonospora sp.

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Two new secondary metabolites, saccharochlorines A and B, from a marine bacterium Saccharomonospora sp. KCTC-19160

Abstract

Bibliographical note

Keywords

UN SDGs

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