Two new Scalaranes from a Korean marine sponge Spongia sp

Inho Yang; Sang Jip Nam; Heonjoong Kang

doi:10.20307/nps.2015.21.4.289

Two new Scalaranes from a Korean marine sponge Spongia sp

Inho Yang, Sang Jip Nam, Heonjoong Kang

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Intensive chemical investigation of Korean marine sponge Spongia sp. has led to the isolation of two new scalaranes. The planar structures of the new compounds 1 and 2 were determined through 1D and 2D NMR spectral data analysis, while the relative stereochemistry of the compounds was determined based on the analysis of ¹H-¹H coupling constants and NOESY spectroscopic data. Compounds 1 and 2 did not display any significant biological activities on farnesoid X-activated receptor (FXR) in co-transfection assay.

Original language	English
Pages (from-to)	289-292
Number of pages	4
Journal	Natural Product Sciences
Volume	21
Issue number	4
DOIs	https://doi.org/10.20307/nps.2015.21.4.289
State	Published - 2015

Bibliographical note

Publisher Copyright:
© 2015, Korean Society of Pharmacognosy. All rights reserved.

Keywords

Korean sponge
Marine natural product
Scalarane
Sesterpenoid
Spongia sp

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10.20307/nps.2015.21.4.289

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abstract = "Intensive chemical investigation of Korean marine sponge Spongia sp. has led to the isolation of two new scalaranes. The planar structures of the new compounds 1 and 2 were determined through 1D and 2D NMR spectral data analysis, while the relative stereochemistry of the compounds was determined based on the analysis of 1H-1H coupling constants and NOESY spectroscopic data. Compounds 1 and 2 did not display any significant biological activities on farnesoid X-activated receptor (FXR) in co-transfection assay.",

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AU - Yang, Inho

AU - Nam, Sang Jip

AU - Kang, Heonjoong

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AB - Intensive chemical investigation of Korean marine sponge Spongia sp. has led to the isolation of two new scalaranes. The planar structures of the new compounds 1 and 2 were determined through 1D and 2D NMR spectral data analysis, while the relative stereochemistry of the compounds was determined based on the analysis of 1H-1H coupling constants and NOESY spectroscopic data. Compounds 1 and 2 did not display any significant biological activities on farnesoid X-activated receptor (FXR) in co-transfection assay.

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KW - Marine natural product

KW - Scalarane

KW - Sesterpenoid

KW - Spongia sp

UR - https://www.scopus.com/pages/publications/84957871578

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DO - 10.20307/nps.2015.21.4.289

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JO - Natural Product Sciences

JF - Natural Product Sciences

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ER -

Two new Scalaranes from a Korean marine sponge Spongia sp

Abstract

Bibliographical note

Keywords

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