Two cases of nontuberculous mycobacterial lung disease in heart transplant recipients

Jung Min Jo, Mi Seon Shin, Joo Hui Kim, Min Jung Kim, Hyun Jung Park, Hee Kyung Na, Kyung Uk Jo, Jae Joong Kim, Tae Sun Shim

Research output: Contribution to journalArticlepeer-review


Nontuberculous mycobacterial (NTM) diseases are increasing worldwide. However NTM lung disease in organ transplant recipients has been rarely reported. Here, we report 2 cases of NTM lung disease in heart transplant recipients. A 37-year-old man, who had undergone a heart transplant one year previous, was admitted to hospital due to a cough. Chest CT scan showed multiple centrilobular nodules in both lower lungs. In his sputum, M. abscessus was repeatedly identified by rpoB gene analysis. The patient improved after treatment with clarithromycin, imipenem, and amikacin. An additional patient, a 53-year-old woman who had undergone a heart transplant 4 years prior and who suffered from bronchiectasis, was admitted because of purulent sputum. The patient's chest CT scan revealed aggravated bronchiectasis; M. intracellulare was isolated repeatedly in her sputum. Treatment was successfully completed with clarithromycin, ethambutol, and ciprofloxacin. NTM lung disease should be considered as a potential opportunistic infection in organ transplant recipients. Copyright

Original languageEnglish
Pages (from-to)201-206
Number of pages6
JournalTuberculosis and Respiratory Diseases
Issue number3
StatePublished - Sep 2010


  • Heart transplantation
  • Lung diseases
  • Mycobacteria, atypical


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