Turning an FDA-approved therapeutic into an AIEgen for imaging live bacteria and for bacterial detection

Juyoung Yoon

doi:10.1002/agt2.47

Turning an FDA-approved therapeutic into an AIEgen for imaging live bacteria and for bacterial detection

Juyoung Yoon

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Aggregation Induced Emission (AIE) is an attractive, fluorescent-based phenomenon that can be used to design fluorescent imaging agents and fluorescent sensors. In this highlight, we discuss a recently reported study that identifies the chemical scaffold of an FDA-approved therapeutic (deferasirox) as a molecule with AIE-like properties (AIEgen). Utilizing its therapeutic efficacy for bacterial biofilms, deferasirox-derivatives were shown able to treat and image bacteria biofilms and detect a bacterial biomarker. This demonstrates the potential of AIE for drug design as this allows the simultaneous ability to image the therapeutic's location and mode of action.

Original language	English
Article number	e47
Journal	Aggregate
Volume	2
Issue number	2
DOIs	https://doi.org/10.1002/agt2.47
State	Published - Apr 2021

Bibliographical note

Publisher Copyright:
© 2021 The Authors. Aggregate published by South China University of Technology; AIE Institute and John Wiley & Sons Australia, Ltd.

Keywords

Aggregation-Induced Emission
Antimicrobials
Fluorescence imaging and Theranostics

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10.1002/agt2.47

Cite this

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title = "Turning an FDA-approved therapeutic into an AIEgen for imaging live bacteria and for bacterial detection",

abstract = "Aggregation Induced Emission (AIE) is an attractive, fluorescent-based phenomenon that can be used to design fluorescent imaging agents and fluorescent sensors. In this highlight, we discuss a recently reported study that identifies the chemical scaffold of an FDA-approved therapeutic (deferasirox) as a molecule with AIE-like properties (AIEgen). Utilizing its therapeutic efficacy for bacterial biofilms, deferasirox-derivatives were shown able to treat and image bacteria biofilms and detect a bacterial biomarker. This demonstrates the potential of AIE for drug design as this allows the simultaneous ability to image the therapeutic's location and mode of action.",

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AB - Aggregation Induced Emission (AIE) is an attractive, fluorescent-based phenomenon that can be used to design fluorescent imaging agents and fluorescent sensors. In this highlight, we discuss a recently reported study that identifies the chemical scaffold of an FDA-approved therapeutic (deferasirox) as a molecule with AIE-like properties (AIEgen). Utilizing its therapeutic efficacy for bacterial biofilms, deferasirox-derivatives were shown able to treat and image bacteria biofilms and detect a bacterial biomarker. This demonstrates the potential of AIE for drug design as this allows the simultaneous ability to image the therapeutic's location and mode of action.

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KW - Antimicrobials

KW - Fluorescence imaging and Theranostics

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ER -

Turning an FDA-approved therapeutic into an AIEgen for imaging live bacteria and for bacterial detection

Abstract

Bibliographical note

Keywords

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