Turning an FDA-approved therapeutic into an AIEgen for imaging live bacteria and for bacterial detection

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6 Scopus citations

Abstract

Aggregation Induced Emission (AIE) is an attractive, fluorescent-based phenomenon that can be used to design fluorescent imaging agents and fluorescent sensors. In this highlight, we discuss a recently reported study that identifies the chemical scaffold of an FDA-approved therapeutic (deferasirox) as a molecule with AIE-like properties (AIEgen). Utilizing its therapeutic efficacy for bacterial biofilms, deferasirox-derivatives were shown able to treat and image bacteria biofilms and detect a bacterial biomarker. This demonstrates the potential of AIE for drug design as this allows the simultaneous ability to image the therapeutic's location and mode of action.

Original languageEnglish
Article numbere47
JournalAggregate
Volume2
Issue number2
DOIs
StatePublished - Apr 2021

Bibliographical note

Publisher Copyright:
© 2021 The Authors. Aggregate published by South China University of Technology; AIE Institute and John Wiley & Sons Australia, Ltd.

Keywords

  • Aggregation-Induced Emission
  • Antimicrobials
  • Fluorescence imaging and Theranostics

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