Tunicate-Inspired Photoactivatable Proteinic Nanobombs for Tumor-Adhesive Multimodal Therapy

Yeonsu Jeong; Yun Kee Jo; Mou Seung Kim; Kye Il Joo; Hyung Joon Cha

doi:10.1002/adhm.202101212

Tunicate-Inspired Photoactivatable Proteinic Nanobombs for Tumor-Adhesive Multimodal Therapy

Yeonsu Jeong, Yun Kee Jo, Mou Seung Kim, Kye Il Joo, Hyung Joon Cha

Department of Chemical Engineering & Materials Science

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Near-IR (NIR) light-responsive multimodal nanotherapeutics have been proposed to achieve improved therapeutic efficacy and high specificity in cancer therapy. However, their clinical application is still elusive due to poor biometabolization and short retention at the target site. Here, innovative photoactivatable vanadium-doped adhesive proteinic nanoparticles (NPs) capable of allowing biological photoabsorption and NIR-responsive anticancer therapeutic effects to realize trimodal photothermal-gas-chemo-therapy treatments in a highly biocompatible, site-specific manner are proposed. The photoactivatable tumor-adhesive proteinic NPs can enable efficient photothermal conversion via tunicate-inspired catechol–vanadium complexes as well as prolonged tumor retention by virtue of mussel protein-driven distinctive adhesiveness. The incorporation of a thermo-sensitive nitric oxide donor and doxorubicin into the photoactivatable adhesive proteinic NPs leads to synergistic anticancer therapeutic effects as a result of photothermal-triggered “bomb-like” multimodal actions. Thus, this protein-based phototherapeutic tumor-adhesive NPs have great potential as a spatiotemporally controllable therapeutic system to accomplish effective therapeutic implications for the complete ablation of cancer.

Original language	English
Article number	2101212
Journal	Advanced Healthcare Materials
Volume	10
Issue number	23
DOIs	https://doi.org/10.1002/adhm.202101212
State	Published - 8 Dec 2021

Bibliographical note

Funding Information:
Y.J. and Y.K.J. contributed equally to this work. The authors acknowledge the financial support by the National Research Foundation grant (NRF‐2018R1A2B3003758 to H.J.C., NRF‐2021R1C1C1008560 to Y.K.J.) funded by the Ministry of Science and ICT, Korea, the Marine BioMaterials Research Center grant (to H.J.C.) funded by the Ministry of Oceans and Fisheries, Korea, and the National Research Foundation grant (NRF‐2019R1A6A3A13096878 to Y.J.) funded by the Ministry of Education, Korea.

Publisher Copyright:
© 2021 Wiley-VCH GmbH

Keywords

NIR-responsive nanotherapeutics
bioinorganic chemistry
multimodal anticancer therapy
protein-based photothermal agents
vanadium-doping effect

Access to Document

10.1002/adhm.202101212

Cite this

@article{b1d307099419481281cc09365bcfb2f6,

title = "Tunicate-Inspired Photoactivatable Proteinic Nanobombs for Tumor-Adhesive Multimodal Therapy",

abstract = "Near-IR (NIR) light-responsive multimodal nanotherapeutics have been proposed to achieve improved therapeutic efficacy and high specificity in cancer therapy. However, their clinical application is still elusive due to poor biometabolization and short retention at the target site. Here, innovative photoactivatable vanadium-doped adhesive proteinic nanoparticles (NPs) capable of allowing biological photoabsorption and NIR-responsive anticancer therapeutic effects to realize trimodal photothermal-gas-chemo-therapy treatments in a highly biocompatible, site-specific manner are proposed. The photoactivatable tumor-adhesive proteinic NPs can enable efficient photothermal conversion via tunicate-inspired catechol–vanadium complexes as well as prolonged tumor retention by virtue of mussel protein-driven distinctive adhesiveness. The incorporation of a thermo-sensitive nitric oxide donor and doxorubicin into the photoactivatable adhesive proteinic NPs leads to synergistic anticancer therapeutic effects as a result of photothermal-triggered “bomb-like” multimodal actions. Thus, this protein-based phototherapeutic tumor-adhesive NPs have great potential as a spatiotemporally controllable therapeutic system to accomplish effective therapeutic implications for the complete ablation of cancer.",

keywords = "NIR-responsive nanotherapeutics, bioinorganic chemistry, multimodal anticancer therapy, protein-based photothermal agents, vanadium-doping effect",

author = "Yeonsu Jeong and Jo, {Yun Kee} and Kim, {Mou Seung} and Joo, {Kye Il} and Cha, {Hyung Joon}",

note = "Funding Information: Y.J. and Y.K.J. contributed equally to this work. The authors acknowledge the financial support by the National Research Foundation grant (NRF‐2018R1A2B3003758 to H.J.C., NRF‐2021R1C1C1008560 to Y.K.J.) funded by the Ministry of Science and ICT, Korea, the Marine BioMaterials Research Center grant (to H.J.C.) funded by the Ministry of Oceans and Fisheries, Korea, and the National Research Foundation grant (NRF‐2019R1A6A3A13096878 to Y.J.) funded by the Ministry of Education, Korea. Publisher Copyright: {\textcopyright} 2021 Wiley-VCH GmbH",

year = "2021",

month = dec,

day = "8",

doi = "10.1002/adhm.202101212",

language = "English",

volume = "10",

journal = "Advanced Healthcare Materials",

issn = "2192-2640",

publisher = "John Wiley and Sons Ltd",

number = "23",

}

TY - JOUR

T1 - Tunicate-Inspired Photoactivatable Proteinic Nanobombs for Tumor-Adhesive Multimodal Therapy

AU - Jeong, Yeonsu

AU - Jo, Yun Kee

AU - Kim, Mou Seung

AU - Joo, Kye Il

AU - Cha, Hyung Joon

N1 - Funding Information: Y.J. and Y.K.J. contributed equally to this work. The authors acknowledge the financial support by the National Research Foundation grant (NRF‐2018R1A2B3003758 to H.J.C., NRF‐2021R1C1C1008560 to Y.K.J.) funded by the Ministry of Science and ICT, Korea, the Marine BioMaterials Research Center grant (to H.J.C.) funded by the Ministry of Oceans and Fisheries, Korea, and the National Research Foundation grant (NRF‐2019R1A6A3A13096878 to Y.J.) funded by the Ministry of Education, Korea. Publisher Copyright: © 2021 Wiley-VCH GmbH

PY - 2021/12/8

Y1 - 2021/12/8

N2 - Near-IR (NIR) light-responsive multimodal nanotherapeutics have been proposed to achieve improved therapeutic efficacy and high specificity in cancer therapy. However, their clinical application is still elusive due to poor biometabolization and short retention at the target site. Here, innovative photoactivatable vanadium-doped adhesive proteinic nanoparticles (NPs) capable of allowing biological photoabsorption and NIR-responsive anticancer therapeutic effects to realize trimodal photothermal-gas-chemo-therapy treatments in a highly biocompatible, site-specific manner are proposed. The photoactivatable tumor-adhesive proteinic NPs can enable efficient photothermal conversion via tunicate-inspired catechol–vanadium complexes as well as prolonged tumor retention by virtue of mussel protein-driven distinctive adhesiveness. The incorporation of a thermo-sensitive nitric oxide donor and doxorubicin into the photoactivatable adhesive proteinic NPs leads to synergistic anticancer therapeutic effects as a result of photothermal-triggered “bomb-like” multimodal actions. Thus, this protein-based phototherapeutic tumor-adhesive NPs have great potential as a spatiotemporally controllable therapeutic system to accomplish effective therapeutic implications for the complete ablation of cancer.

AB - Near-IR (NIR) light-responsive multimodal nanotherapeutics have been proposed to achieve improved therapeutic efficacy and high specificity in cancer therapy. However, their clinical application is still elusive due to poor biometabolization and short retention at the target site. Here, innovative photoactivatable vanadium-doped adhesive proteinic nanoparticles (NPs) capable of allowing biological photoabsorption and NIR-responsive anticancer therapeutic effects to realize trimodal photothermal-gas-chemo-therapy treatments in a highly biocompatible, site-specific manner are proposed. The photoactivatable tumor-adhesive proteinic NPs can enable efficient photothermal conversion via tunicate-inspired catechol–vanadium complexes as well as prolonged tumor retention by virtue of mussel protein-driven distinctive adhesiveness. The incorporation of a thermo-sensitive nitric oxide donor and doxorubicin into the photoactivatable adhesive proteinic NPs leads to synergistic anticancer therapeutic effects as a result of photothermal-triggered “bomb-like” multimodal actions. Thus, this protein-based phototherapeutic tumor-adhesive NPs have great potential as a spatiotemporally controllable therapeutic system to accomplish effective therapeutic implications for the complete ablation of cancer.

KW - NIR-responsive nanotherapeutics

KW - bioinorganic chemistry

KW - multimodal anticancer therapy

KW - protein-based photothermal agents

KW - vanadium-doping effect

UR - http://www.scopus.com/inward/record.url?scp=85117206634&partnerID=8YFLogxK

U2 - 10.1002/adhm.202101212

DO - 10.1002/adhm.202101212

M3 - Article

C2 - 34626527

AN - SCOPUS:85117206634

SN - 2192-2640

VL - 10

JO - Advanced Healthcare Materials

JF - Advanced Healthcare Materials

IS - 23

M1 - 2101212

ER -

Tunicate-Inspired Photoactivatable Proteinic Nanobombs for Tumor-Adhesive Multimodal Therapy

Abstract

Bibliographical note

Keywords

Access to Document

Fingerprint

Cite this