Tumor-targeting gold particles for dual computed tomography/optical cancer imaging

In Cheol Sun; Dae Kyung Eun; Heebeom Koo; Chang Yong Ko; Han Sung Kim; Dong Kee Yi; Kuiwon Choi; Ick Chan Kwon; Kwangmeyung Kim; Cheol Hee Ahn

doi:10.1002/anie.201102892

Tumor-targeting gold particles for dual computed tomography/optical cancer imaging

In Cheol Sun
, Dae Kyung Eun
, Heebeom Koo
, Chang Yong Ko
, Han Sung Kim
, Dong Kee Yi
, Kuiwon Choi
, Ick Chan Kwon
, Kwangmeyung Kim
, Cheol Hee Ahn

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

Abstract

Double spotlight: A dual imaging probe with gold nanoparticles (AuNPs) for computed tomography (CT) and optical imaging exhibits have been developed (see picture). The excellent stability, tumor targeting ability, enhanced X-ray absorption, and matrix metalloproteinase (MMP) activatable fluorescence recovery was achieved by surface modification of AuNPs with glycol chitosan and fluorescent MMP peptide probes.

Original language	English
Pages (from-to)	9348-9351
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	40
DOIs	https://doi.org/10.1002/anie.201102892
State	Published - 26 Sep 2011

Keywords

computed tomography
gold
imaging agents
nanoparticles

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10.1002/anie.201102892

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title = "Tumor-targeting gold particles for dual computed tomography/optical cancer imaging",

abstract = "Double spotlight: A dual imaging probe with gold nanoparticles (AuNPs) for computed tomography (CT) and optical imaging exhibits have been developed (see picture). The excellent stability, tumor targeting ability, enhanced X-ray absorption, and matrix metalloproteinase (MMP) activatable fluorescence recovery was achieved by surface modification of AuNPs with glycol chitosan and fluorescent MMP peptide probes.",

keywords = "computed tomography, gold, imaging agents, nanoparticles",

author = "Sun, \{In Cheol\} and Eun, \{Dae Kyung\} and Heebeom Koo and Ko, \{Chang Yong\} and Kim, \{Han Sung\} and Yi, \{Dong Kee\} and Kuiwon Choi and Kwon, \{Ick Chan\} and Kwangmeyung Kim and Ahn, \{Cheol Hee\}",

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T1 - Tumor-targeting gold particles for dual computed tomography/optical cancer imaging

AU - Sun, In Cheol

AU - Eun, Dae Kyung

AU - Koo, Heebeom

AU - Ko, Chang Yong

AU - Kim, Han Sung

AU - Yi, Dong Kee

AU - Choi, Kuiwon

AU - Kwon, Ick Chan

AU - Kim, Kwangmeyung

AU - Ahn, Cheol Hee

PY - 2011/9/26

Y1 - 2011/9/26

N2 - Double spotlight: A dual imaging probe with gold nanoparticles (AuNPs) for computed tomography (CT) and optical imaging exhibits have been developed (see picture). The excellent stability, tumor targeting ability, enhanced X-ray absorption, and matrix metalloproteinase (MMP) activatable fluorescence recovery was achieved by surface modification of AuNPs with glycol chitosan and fluorescent MMP peptide probes.

AB - Double spotlight: A dual imaging probe with gold nanoparticles (AuNPs) for computed tomography (CT) and optical imaging exhibits have been developed (see picture). The excellent stability, tumor targeting ability, enhanced X-ray absorption, and matrix metalloproteinase (MMP) activatable fluorescence recovery was achieved by surface modification of AuNPs with glycol chitosan and fluorescent MMP peptide probes.

KW - computed tomography

KW - gold

KW - imaging agents

KW - nanoparticles

UR - https://www.scopus.com/pages/publications/80053136204

U2 - 10.1002/anie.201102892

DO - 10.1002/anie.201102892

M3 - Article

C2 - 21948430

AN - SCOPUS:80053136204

SN - 1433-7851

VL - 50

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EP - 9351

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 40

ER -

Tumor-targeting gold particles for dual computed tomography/optical cancer imaging

Abstract

Keywords

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