Tumor-targeting gold particles for dual computed tomography/optical cancer imaging

In Cheol Sun; Dae Kyung Eun; Heebeom Koo; Chang Yong Ko; Han Sung Kim; Dong Kee Yi; Kuiwon Choi; Ick Chan Kwon; Kwangmeyung Kim; Cheol Hee Ahn

doi:10.1002/anie.201102892

Tumor-targeting gold particles for dual computed tomography/optical cancer imaging

In Cheol Sun, Dae Kyung Eun, Heebeom Koo, Chang Yong Ko, Han Sung Kim, Dong Kee Yi, Kuiwon Choi, Ick Chan Kwon, Kwangmeyung Kim, Cheol Hee Ahn

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

117 Scopus citations

Abstract

Double spotlight: A dual imaging probe with gold nanoparticles (AuNPs) for computed tomography (CT) and optical imaging exhibits have been developed (see picture). The excellent stability, tumor targeting ability, enhanced X-ray absorption, and matrix metalloproteinase (MMP) activatable fluorescence recovery was achieved by surface modification of AuNPs with glycol chitosan and fluorescent MMP peptide probes.

Original language	English
Pages (from-to)	9348-9351
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	40
DOIs	https://doi.org/10.1002/anie.201102892
State	Published - 26 Sep 2011

Keywords

computed tomography
gold
imaging agents
nanoparticles

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10.1002/anie.201102892

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abstract = "Double spotlight: A dual imaging probe with gold nanoparticles (AuNPs) for computed tomography (CT) and optical imaging exhibits have been developed (see picture). The excellent stability, tumor targeting ability, enhanced X-ray absorption, and matrix metalloproteinase (MMP) activatable fluorescence recovery was achieved by surface modification of AuNPs with glycol chitosan and fluorescent MMP peptide probes.",

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AU - Sun, In Cheol

AU - Eun, Dae Kyung

AU - Koo, Heebeom

AU - Ko, Chang Yong

AU - Kim, Han Sung

AU - Yi, Dong Kee

AU - Choi, Kuiwon

AU - Kwon, Ick Chan

AU - Kim, Kwangmeyung

AU - Ahn, Cheol Hee

PY - 2011/9/26

Y1 - 2011/9/26

N2 - Double spotlight: A dual imaging probe with gold nanoparticles (AuNPs) for computed tomography (CT) and optical imaging exhibits have been developed (see picture). The excellent stability, tumor targeting ability, enhanced X-ray absorption, and matrix metalloproteinase (MMP) activatable fluorescence recovery was achieved by surface modification of AuNPs with glycol chitosan and fluorescent MMP peptide probes.

AB - Double spotlight: A dual imaging probe with gold nanoparticles (AuNPs) for computed tomography (CT) and optical imaging exhibits have been developed (see picture). The excellent stability, tumor targeting ability, enhanced X-ray absorption, and matrix metalloproteinase (MMP) activatable fluorescence recovery was achieved by surface modification of AuNPs with glycol chitosan and fluorescent MMP peptide probes.

KW - computed tomography

KW - gold

KW - imaging agents

KW - nanoparticles

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JF - Angewandte Chemie - International Edition

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Tumor-targeting gold particles for dual computed tomography/optical cancer imaging

Abstract

Keywords

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