Tumor necrosis factor receptor superfamily 12 may destabilize atherosclerotic plaques by inducing matrix metalloproteinases

S. H. Kim, W. H. Lee, B. S. Kwon, Taeg Oh Goo Taeg Oh, Y. H. Choi, J. E. Park

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Immunohistochemical staining of human atherosclerotic plaques revealed expression of the tumor necrosis factor receptor superfamily (TNFRSF) 12 in regions rich in macrophage/foam cells. The role of TNFRSF12 in the functioning of monocytes in relation to atherogenesis was investigated by analysis of cellular events after stimulation of TNFRSF12 in a human macrophage-like cell line, THP-1. Activation of the THP-1 cells on plates coated with monoclonal antibody against TNFRSF12 induced the expression of matrix metalloproteinases (MMPs) -1, -9, and -13. Furthermore, the expression patterns of TNFRSF12 and the MMPs overlapped in atherosclerotic plaques. Signaling of TNFRSF12 may thus contribute to the induction of extracellular matrix degrading enzymes in macrophages.

Original languageEnglish
Pages (from-to)136-138
Number of pages3
JournalJapanese Circulation Journal
Volume65
Issue number2
DOIs
StatePublished - 2001

Keywords

  • Atherosclerosis
  • Matrix metalloproteinase
  • Tumor necrosis factor receptor superfamily

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