Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment

So Jin Lee; Myung Sook Huh; Seung Young Lee; Solki Min; Seulki Lee; Heebeom Koo; Jun Uk Chu; Kyung Eun Lee; Hyesung Jeon; Yongseok Choi; Kuiwon Choi; Youngro Byun; Seo Young Jeong; Kinam Park; Kwangmeyung Kim; Ick Chan Kwon

doi:10.1002/anie.201201390

Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment

So Jin Lee
, Myung Sook Huh
, Seung Young Lee
, Solki Min
, Seulki Lee
, Heebeom Koo
, Jun Uk Chu
, Kyung Eun Lee
, Hyesung Jeon
, Yongseok Choi
, Kuiwon Choi
, Youngro Byun
, Seo Young Jeong
, Kinam Park
, Kwangmeyung Kim
, Ick Chan Kwon

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

156 Scopus citations

Abstract

The condensed version: Thiolated glycol chitosan can form stable nanoparticles with polymerized siRNAs through charge-charge interactions and self-cross-linking (see scheme). This poly-siRNA/glycol chitosan nanoparticles (psi-TGC) provided sufficient in vivo stability for systemic delivery of siRNAs. Knockdown of tumor proteins by psi-TGC resulted in a reduction in tumor size and vascularization.

Original language	English
Pages (from-to)	7203-7207
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	29
DOIs	https://doi.org/10.1002/anie.201201390
State	Published - 16 Jul 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antitumor agents
Glycol chitosan
Nanoparticles
Poly-siRNA
SiRNA delivery

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10.1002/anie.201201390

Cite this

Lee, S. J., Huh, M. S., Lee, S. Y., Min, S., Lee, S., Koo, H., Chu, J. U., Lee, K. E., Jeon, H., Choi, Y., Choi, K., Byun, Y., Jeong, S. Y., Park, K., Kim, K., & Kwon, I. C. (2012). Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment. Angewandte Chemie - International Edition, 51(29), 7203-7207. https://doi.org/10.1002/anie.201201390

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title = "Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment",

abstract = "The condensed version: Thiolated glycol chitosan can form stable nanoparticles with polymerized siRNAs through charge-charge interactions and self-cross-linking (see scheme). This poly-siRNA/glycol chitosan nanoparticles (psi-TGC) provided sufficient in vivo stability for systemic delivery of siRNAs. Knockdown of tumor proteins by psi-TGC resulted in a reduction in tumor size and vascularization.",

keywords = "Antitumor agents, Glycol chitosan, Nanoparticles, Poly-siRNA, SiRNA delivery",

author = "Lee, \{So Jin\} and Huh, \{Myung Sook\} and Lee, \{Seung Young\} and Solki Min and Seulki Lee and Heebeom Koo and Chu, \{Jun Uk\} and Lee, \{Kyung Eun\} and Hyesung Jeon and Yongseok Choi and Kuiwon Choi and Youngro Byun and Jeong, \{Seo Young\} and Kinam Park and Kwangmeyung Kim and Kwon, \{Ick Chan\}",

year = "2012",

month = jul,

day = "16",

doi = "10.1002/anie.201201390",

language = "English",

volume = "51",

pages = "7203--7207",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "29",

}

Lee, SJ, Huh, MS, Lee, SY, Min, S, Lee, S, Koo, H, Chu, JU, Lee, KE, Jeon, H, Choi, Y, Choi, K, Byun, Y, Jeong, SY, Park, K, Kim, K & Kwon, IC 2012, 'Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment', Angewandte Chemie - International Edition, vol. 51, no. 29, pp. 7203-7207. https://doi.org/10.1002/anie.201201390

TY - JOUR

T1 - Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment

AU - Lee, So Jin

AU - Huh, Myung Sook

AU - Lee, Seung Young

AU - Min, Solki

AU - Lee, Seulki

AU - Koo, Heebeom

AU - Chu, Jun Uk

AU - Lee, Kyung Eun

AU - Jeon, Hyesung

AU - Choi, Yongseok

AU - Choi, Kuiwon

AU - Byun, Youngro

AU - Jeong, Seo Young

AU - Park, Kinam

AU - Kim, Kwangmeyung

AU - Kwon, Ick Chan

PY - 2012/7/16

Y1 - 2012/7/16

N2 - The condensed version: Thiolated glycol chitosan can form stable nanoparticles with polymerized siRNAs through charge-charge interactions and self-cross-linking (see scheme). This poly-siRNA/glycol chitosan nanoparticles (psi-TGC) provided sufficient in vivo stability for systemic delivery of siRNAs. Knockdown of tumor proteins by psi-TGC resulted in a reduction in tumor size and vascularization.

AB - The condensed version: Thiolated glycol chitosan can form stable nanoparticles with polymerized siRNAs through charge-charge interactions and self-cross-linking (see scheme). This poly-siRNA/glycol chitosan nanoparticles (psi-TGC) provided sufficient in vivo stability for systemic delivery of siRNAs. Knockdown of tumor proteins by psi-TGC resulted in a reduction in tumor size and vascularization.

KW - Antitumor agents

KW - Glycol chitosan

KW - Nanoparticles

KW - Poly-siRNA

KW - SiRNA delivery

UR - https://www.scopus.com/pages/publications/84863848240

U2 - 10.1002/anie.201201390

DO - 10.1002/anie.201201390

M3 - Article

C2 - 22696263

AN - SCOPUS:84863848240

SN - 1433-7851

VL - 51

SP - 7203

EP - 7207

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 29

ER -

Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment

Abstract

UN SDGs

Keywords

Access to Document

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