@article{d6eca00e03e7401db60f692f303c7b39,
title = "Tumor-derived exosomal miR-619-5p promotes tumor angiogenesis and metastasis through the inhibition of RCAN1.4",
abstract = "Tumor-derived exosomes (TEXs) contain enriched miRNAs that act as novel non-invasive biomarkers for cancer diagnosis and play a role in cancer progression. We investigated the exosomal miRNAs that affect cancer progression in non-small cell lung cancer (NSCLC) and identified the specific molecules involved. We identified that specific miRNAs in NSCLC cell-released exosomes can modulate angiogenesis, among which miR-619-5p was the most potent inducer. RCAN1.4 was identified as a target of miR-619-5p and its suppression promoted angiogenesis. Furthermore, the suppression of RCAN1.4 induced cell proliferation and metastasis in NSCLC cells. In patients with NSCLC, the level of RCAN1.4 expression was significantly lower, and that of miR-619-5p significantly higher, in tumor than normal lung tissues. miR-619-5p expression was higher than normal in exosomes isolated from the plasma of NSCLC patients. Finally, hypoxic conditions induced miR-619-5p upload into NSCLC cell-derived exosomes. Our findings indicate that exosomal miR-619-5p promotes the growth and metastasis of NSCLCs by regulating RCAN1.4 and can serve as a diagnostic indicator for these lung cancers.",
keywords = "Exosomal miRNAs, Exosome, Non-small cell lung cancer, RCAN1, Tumor growth",
author = "Kim, {Dong Ha} and Sojung Park and Kim, {Hyeong Ryul} and Choi, {Yun Jung} and Kim, {Seon Ye} and Sung, {Ki Jung} and Sung, {Young Hoon} and Choi, {Chang Min} and Miyong Yun and Yi, {Young Su} and Lee, {Chae Won} and Kim, {Sang Yeob} and Lee, {Jae Cheol} and Rho, {Jin Kyung}",
note = "Funding Information: We thank the core facilities of Confocal Microscopy Core, Optical Imaging Core and the Laboratory of Animal Research at the ConveRgence mEDIcine research center (CREDIT), Asan Medical Center for the use of their shared equipment, services and expertise. The biospecimen and data used in this study was provided by Asan Bio-Resource Center, Korea Biobank Network (2018–11(165)). This study was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government ( 2019R1C1C1007262 to D.H. Kim and 2019R1A2C2006054 to J.K. Rho) and a grant of the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea ( 1631130 to J.K. Rho) and a grant ( 2019-563 to J.K. Rho and 2019-709 to J.C. Lee) from the Asan Institute for Life Sciences, Seoul, Korea . Funding Information: We thank the core facilities of Confocal Microscopy Core, Optical Imaging Core and the Laboratory of Animal Research at the ConveRgence mEDIcine research center (CREDIT), Asan Medical Center for the use of their shared equipment, services and expertise. The biospecimen and data used in this study was provided by Asan Bio-Resource Center, Korea Biobank Network (2018?11(165)). This study was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (2019R1C1C1007262 to D.H. Kim and 2019R1A2C2006054 to J.K. Rho) and a grant of the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea (1631130 to J.K. Rho) and a grant (2019-563 to J.K. Rho and 2019-709 to J.C. Lee) from the Asan Institute for Life Sciences, Seoul, Korea. Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",
year = "2020",
month = apr,
day = "10",
doi = "10.1016/j.canlet.2020.01.023",
language = "English",
volume = "475",
pages = "2--13",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
}
