@article{3db684fae01d4c6e937c7261855b4b29,
title = "Tsaokoic Acid: A New Bicyclic Nonene from the Fruits of Amomum tsao-ko with Acetylcholinesterase Inhibitory Activity",
abstract = "A new bicyclic nonene, tsaokoic acid (1), was isolated from the fruits of Amomum tsao-ko, together with three known compounds (2–4). The structure of 1 was elucidated by analyzing spectroscopic data including 1D and 2D NMR spectra and compounds 2–4 were identified as tsaokoin, vanillin, and tsaokoarylone, respectively, by comparing their NMR spectra with previously reported data. Compounds 1–4 showed possible inhibitory activity against acetylcholinesterase (AChE) in silico molecular docking simulations. They were submitted to in vitro assay system and exhibited moderate inhibitory activity with IC50 values of 32.78, 41.70, 39.25, and 31.13 μM, respectively.",
keywords = "Amomum tsao-ko, Zingiberaceae, acetylcholinesterase, bicyclic nonene",
author = "Hyunyoung Kim and Hwaryeong Lee and Jung, {Hee Jin} and Noh, {Sang Gyun} and Isoo Youn and Hyunkyung Kwak and Yeju Lee and Nam, {Sang Jip} and Soosung Kang and Chung, {Hae Young} and Seo, {Eun Kyoung}",
note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MIST) (No. 2021R1A2C1003350). This research was supported by Korea Basic Science Institute (National research Facilities and Equipment Center) grant funded by the Ministry of Education (2021R1A6C101A442). Publisher Copyright: {\textcopyright} 2023 by the authors.",
year = "2023",
month = mar,
doi = "10.3390/molecules28062602",
language = "English",
volume = "28",
journal = "Molecules",
issn = "1420-3049",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "6",
}