Tripartin, a histone demethylase inhibitor from a bacterium associated with a dung beetle larva

Seong Hwan Kim; So Hee Kwon; Seon Hui Park; Jae Kyun Lee; Hea Son Bang; Sang Jip Nam; Hak Cheol Kwon; Jongheon Shin; Dong Chan Oh

doi:10.1021/ol4004417

Tripartin, a histone demethylase inhibitor from a bacterium associated with a dung beetle larva

Seong Hwan Kim, So Hee Kwon, Seon Hui Park, Jae Kyun Lee, Hea Son Bang, Sang Jip Nam, Hak Cheol Kwon, Jongheon Shin, Dong Chan Oh

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

Tripartin (1), a new dichlorinated indanone, was isolated from the culture broth of the Streptomyces sp. associated with a larva of the dung beetle Copris tripartitus Waterhouse. The planar structure of tripartin (1) was identified by the spectroscopic analyses of NMR, mass, UV, and IR data. The structure was confirmed, and the absolute configuration of 1 was determined by X-ray crystallography. Tripartin displayed specific activity as an inhibitor of the histone H3 lysine 9 demethylase KDM4 in HeLa cells.

Original language	English
Pages (from-to)	1834-1837
Number of pages	4
Journal	Organic Letters
Volume	15
Issue number	8
DOIs	https://doi.org/10.1021/ol4004417
State	Published - 19 Apr 2013

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abstract = "Tripartin (1), a new dichlorinated indanone, was isolated from the culture broth of the Streptomyces sp. associated with a larva of the dung beetle Copris tripartitus Waterhouse. The planar structure of tripartin (1) was identified by the spectroscopic analyses of NMR, mass, UV, and IR data. The structure was confirmed, and the absolute configuration of 1 was determined by X-ray crystallography. Tripartin displayed specific activity as an inhibitor of the histone H3 lysine 9 demethylase KDM4 in HeLa cells.",

author = "Kim, {Seong Hwan} and Kwon, {So Hee} and Park, {Seon Hui} and Lee, {Jae Kyun} and Bang, {Hea Son} and Nam, {Sang Jip} and Kwon, {Hak Cheol} and Jongheon Shin and Oh, {Dong Chan}",

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T1 - Tripartin, a histone demethylase inhibitor from a bacterium associated with a dung beetle larva

AU - Kim, Seong Hwan

AU - Kwon, So Hee

AU - Park, Seon Hui

AU - Lee, Jae Kyun

AU - Bang, Hea Son

AU - Nam, Sang Jip

AU - Kwon, Hak Cheol

AU - Shin, Jongheon

AU - Oh, Dong Chan

PY - 2013/4/19

Y1 - 2013/4/19

N2 - Tripartin (1), a new dichlorinated indanone, was isolated from the culture broth of the Streptomyces sp. associated with a larva of the dung beetle Copris tripartitus Waterhouse. The planar structure of tripartin (1) was identified by the spectroscopic analyses of NMR, mass, UV, and IR data. The structure was confirmed, and the absolute configuration of 1 was determined by X-ray crystallography. Tripartin displayed specific activity as an inhibitor of the histone H3 lysine 9 demethylase KDM4 in HeLa cells.

AB - Tripartin (1), a new dichlorinated indanone, was isolated from the culture broth of the Streptomyces sp. associated with a larva of the dung beetle Copris tripartitus Waterhouse. The planar structure of tripartin (1) was identified by the spectroscopic analyses of NMR, mass, UV, and IR data. The structure was confirmed, and the absolute configuration of 1 was determined by X-ray crystallography. Tripartin displayed specific activity as an inhibitor of the histone H3 lysine 9 demethylase KDM4 in HeLa cells.

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VL - 15

SP - 1834

EP - 1837

JO - Organic Letters

JF - Organic Letters

IS - 8

ER -

Tripartin, a histone demethylase inhibitor from a bacterium associated with a dung beetle larva

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