Treatment outcomes and prognostic factors in patients with multidrug-resistant tuberculosis in Korean private hospitals

Jin Kyeong Park; Won Jung Koh; Deog Kyeom Kim; Eun Kyung Kim; Yu Il Kim; Hee Jin Kim; Tae Hyung Kim; Jae Yeol Kim; Moo Suk Park; I. Nae Park; Jae Seuk Park; Ki Man Lee; Sook Hee Song; Jin Hwa Lee; Seung Heon Lee; Hyuk Pyo Lee; Jae Joon Yim; Jaemin Lim; Yang Jin Jegal; Ki Hwan Jung; Jin Won Huh; Jae Choi Choi; Tae Sun Shim

doi:10.4046/trd.2010.69.2.95

Treatment outcomes and prognostic factors in patients with multidrug-resistant tuberculosis in Korean private hospitals

Jin Kyeong Park, Won Jung Koh, Deog Kyeom Kim, Eun Kyung Kim, Yu Il Kim, Hee Jin Kim, Tae Hyung Kim, Jae Yeol Kim, Moo Suk Park, I. Nae Park, Jae Seuk Park, Ki Man Lee, Sook Hee Song, Jin Hwa Lee, Seung Heon Lee, Hyuk Pyo Lee, Jae Joon Yim, Jaemin Lim, Yang Jin Jegal, Ki Hwan JungJin Won Huh, Jae Choi Choi, Tae Sun Shim

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Background: The increasing rate of drug-resistant tuberculosis (TB) is a threat to the public health and TB control. In Korea, about 75-80% of TB patients are treated in private hospitals and the rate has been continuously increasing since 2000. Methods: On a retrospective basis, we enrolled 170 newly diagnosed with or retreated for multidrug-resistant TB (MDR-TB) in 2004 from 21 private hospitals. We extracted the following demographics and treatment history from patient medical records: initial treatment outcomes, cumulative survival rates, treatment outcomes, and prognostic factors. Results: Of the 170 patients, the majority were male (64.1%), the mean age was 44.5 years old, and mean body-mass-index was 20.2 kg/m². None of the patients tested positive for HIV. Eleven (6.5%) were confirmed to have extensively drug-resistant TB (XDR-TB) at treatment initiation. Treatment success rates were not different between XDR-TB (36.4%, 4/11) and non-XDR MDR-TB (51.6%, 82/159). Default rate was high, 21.8% (37/170). Far advanced disease on X-ray was a significant negative predictor of treatment success; advanced disease and low BMI were risk factors for all-cause mortality. Conclusion: In private hospitals in Korea, the proportion of XDR-TB in MDR-TB was comparable to previous data. The treatment success rate of MDR-/XDR-TB remains poor and the failure rate was quite high. Adequate TB control policies should be strengthened to prevent the further development and spread of MDR-/XDR-TB in Korea. Copyright

Original language	English
Pages (from-to)	95-102
Number of pages	8
Journal	Tuberculosis and Respiratory Diseases
Volume	69
Issue number	2
DOIs	https://doi.org/10.4046/trd.2010.69.2.95
State	Published - Aug 2010

Keywords

Extensively drug-resistant tuberculosis
Hospitals, private
Korea
Tuberculosis, multidrug-resistant

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4046/trd.2010.69.2.95

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Park, J. K., Koh, W. J., Kim, D. K., Kim, E. K., Kim, Y. I., Kim, H. J., Kim, T. H., Kim, J. Y., Park, M. S., Park, I. N., Park, J. S., Lee, K. M., Song, S. H., Lee, J. H., Lee, S. H., Lee, H. P., Yim, J. J., Lim, J., Jegal, Y. J., ... Shim, T. S. (2010). Treatment outcomes and prognostic factors in patients with multidrug-resistant tuberculosis in Korean private hospitals. Tuberculosis and Respiratory Diseases, 69(2), 95-102. https://doi.org/10.4046/trd.2010.69.2.95

@article{c7dc604385004f07a9b15ebc82d79321,

title = "Treatment outcomes and prognostic factors in patients with multidrug-resistant tuberculosis in Korean private hospitals",

abstract = "Background: The increasing rate of drug-resistant tuberculosis (TB) is a threat to the public health and TB control. In Korea, about 75-80% of TB patients are treated in private hospitals and the rate has been continuously increasing since 2000. Methods: On a retrospective basis, we enrolled 170 newly diagnosed with or retreated for multidrug-resistant TB (MDR-TB) in 2004 from 21 private hospitals. We extracted the following demographics and treatment history from patient medical records: initial treatment outcomes, cumulative survival rates, treatment outcomes, and prognostic factors. Results: Of the 170 patients, the majority were male (64.1%), the mean age was 44.5 years old, and mean body-mass-index was 20.2 kg/m2. None of the patients tested positive for HIV. Eleven (6.5%) were confirmed to have extensively drug-resistant TB (XDR-TB) at treatment initiation. Treatment success rates were not different between XDR-TB (36.4%, 4/11) and non-XDR MDR-TB (51.6%, 82/159). Default rate was high, 21.8% (37/170). Far advanced disease on X-ray was a significant negative predictor of treatment success; advanced disease and low BMI were risk factors for all-cause mortality. Conclusion: In private hospitals in Korea, the proportion of XDR-TB in MDR-TB was comparable to previous data. The treatment success rate of MDR-/XDR-TB remains poor and the failure rate was quite high. Adequate TB control policies should be strengthened to prevent the further development and spread of MDR-/XDR-TB in Korea. Copyright",

keywords = "Extensively drug-resistant tuberculosis, Hospitals, private, Korea, Tuberculosis, multidrug-resistant",

author = "Park, {Jin Kyeong} and Koh, {Won Jung} and Kim, {Deog Kyeom} and Kim, {Eun Kyung} and Kim, {Yu Il} and Kim, {Hee Jin} and Kim, {Tae Hyung} and Kim, {Jae Yeol} and Park, {Moo Suk} and Park, {I. Nae} and Park, {Jae Seuk} and Lee, {Ki Man} and Song, {Sook Hee} and Lee, {Jin Hwa} and Lee, {Seung Heon} and Lee, {Hyuk Pyo} and Yim, {Jae Joon} and Jaemin Lim and Jegal, {Yang Jin} and Jung, {Ki Hwan} and Huh, {Jin Won} and Choi, {Jae Choi} and Shim, {Tae Sun}",

year = "2010",

month = aug,

doi = "10.4046/trd.2010.69.2.95",

language = "English",

volume = "69",

pages = "95--102",

journal = "Tuberculosis and Respiratory Diseases",

issn = "1738-3536",

publisher = "The Korean Academy of Tuberculosis and Respiratory Diseases",

number = "2",

}

Park, JK, Koh, WJ, Kim, DK, Kim, EK, Kim, YI, Kim, HJ, Kim, TH, Kim, JY, Park, MS, Park, IN, Park, JS, Lee, KM, Song, SH, Lee, JH, Lee, SH, Lee, HP, Yim, JJ, Lim, J, Jegal, YJ, Jung, KH, Huh, JW, Choi, JC & Shim, TS 2010, 'Treatment outcomes and prognostic factors in patients with multidrug-resistant tuberculosis in Korean private hospitals', Tuberculosis and Respiratory Diseases, vol. 69, no. 2, pp. 95-102. https://doi.org/10.4046/trd.2010.69.2.95

TY - JOUR

T1 - Treatment outcomes and prognostic factors in patients with multidrug-resistant tuberculosis in Korean private hospitals

AU - Park, Jin Kyeong

AU - Koh, Won Jung

AU - Kim, Deog Kyeom

AU - Kim, Eun Kyung

AU - Kim, Yu Il

AU - Kim, Hee Jin

AU - Kim, Tae Hyung

AU - Kim, Jae Yeol

AU - Park, Moo Suk

AU - Park, I. Nae

AU - Park, Jae Seuk

AU - Lee, Ki Man

AU - Song, Sook Hee

AU - Lee, Jin Hwa

AU - Lee, Seung Heon

AU - Lee, Hyuk Pyo

AU - Yim, Jae Joon

AU - Lim, Jaemin

AU - Jegal, Yang Jin

AU - Jung, Ki Hwan

AU - Huh, Jin Won

AU - Choi, Jae Choi

AU - Shim, Tae Sun

PY - 2010/8

Y1 - 2010/8

N2 - Background: The increasing rate of drug-resistant tuberculosis (TB) is a threat to the public health and TB control. In Korea, about 75-80% of TB patients are treated in private hospitals and the rate has been continuously increasing since 2000. Methods: On a retrospective basis, we enrolled 170 newly diagnosed with or retreated for multidrug-resistant TB (MDR-TB) in 2004 from 21 private hospitals. We extracted the following demographics and treatment history from patient medical records: initial treatment outcomes, cumulative survival rates, treatment outcomes, and prognostic factors. Results: Of the 170 patients, the majority were male (64.1%), the mean age was 44.5 years old, and mean body-mass-index was 20.2 kg/m2. None of the patients tested positive for HIV. Eleven (6.5%) were confirmed to have extensively drug-resistant TB (XDR-TB) at treatment initiation. Treatment success rates were not different between XDR-TB (36.4%, 4/11) and non-XDR MDR-TB (51.6%, 82/159). Default rate was high, 21.8% (37/170). Far advanced disease on X-ray was a significant negative predictor of treatment success; advanced disease and low BMI were risk factors for all-cause mortality. Conclusion: In private hospitals in Korea, the proportion of XDR-TB in MDR-TB was comparable to previous data. The treatment success rate of MDR-/XDR-TB remains poor and the failure rate was quite high. Adequate TB control policies should be strengthened to prevent the further development and spread of MDR-/XDR-TB in Korea. Copyright

AB - Background: The increasing rate of drug-resistant tuberculosis (TB) is a threat to the public health and TB control. In Korea, about 75-80% of TB patients are treated in private hospitals and the rate has been continuously increasing since 2000. Methods: On a retrospective basis, we enrolled 170 newly diagnosed with or retreated for multidrug-resistant TB (MDR-TB) in 2004 from 21 private hospitals. We extracted the following demographics and treatment history from patient medical records: initial treatment outcomes, cumulative survival rates, treatment outcomes, and prognostic factors. Results: Of the 170 patients, the majority were male (64.1%), the mean age was 44.5 years old, and mean body-mass-index was 20.2 kg/m2. None of the patients tested positive for HIV. Eleven (6.5%) were confirmed to have extensively drug-resistant TB (XDR-TB) at treatment initiation. Treatment success rates were not different between XDR-TB (36.4%, 4/11) and non-XDR MDR-TB (51.6%, 82/159). Default rate was high, 21.8% (37/170). Far advanced disease on X-ray was a significant negative predictor of treatment success; advanced disease and low BMI were risk factors for all-cause mortality. Conclusion: In private hospitals in Korea, the proportion of XDR-TB in MDR-TB was comparable to previous data. The treatment success rate of MDR-/XDR-TB remains poor and the failure rate was quite high. Adequate TB control policies should be strengthened to prevent the further development and spread of MDR-/XDR-TB in Korea. Copyright

KW - Extensively drug-resistant tuberculosis

KW - Hospitals, private

KW - Korea

KW - Tuberculosis, multidrug-resistant

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U2 - 10.4046/trd.2010.69.2.95

DO - 10.4046/trd.2010.69.2.95

M3 - Article

AN - SCOPUS:77956675840

SN - 1738-3536

VL - 69

SP - 95

EP - 102

JO - Tuberculosis and Respiratory Diseases

JF - Tuberculosis and Respiratory Diseases

IS - 2

ER -

Treatment outcomes and prognostic factors in patients with multidrug-resistant tuberculosis in Korean private hospitals

Abstract

Keywords

UN SDGs

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