Transition metal-catalyzed site- and regio-divergent C-H bond functionalization

Lucy Ping, Da Sol Chung, Jean Bouffard, Sang Gi Lee

Research output: Contribution to journalReview articlepeer-review

322 Scopus citations

Abstract

Recent advances in transition metal-catalyzed C-H bond functionalization have profoundly impacted synthetic strategy. Since organic substrates typically contain several chemically distinct C-H bonds, controlling the regioselectivity of C-H bond functionalization is imperative to harness its full potential. Moreover, the ability to alter reaction pathways to selectively functionalize different C-H bonds in a substrate represents a greater opportunity and challenge. The choice of catalysts, ligands, solvents, and even more subtle variations of the reaction conditions have been shown to allow the formation of regioisomeric C-H functionalization products starting from the same precursors. This review describes recent advances in transition metal-catalyzed divergent C-H bond functionalization that highlight its potential in organic synthesis.

Original languageEnglish
Pages (from-to)4299-4328
Number of pages30
JournalChemical Society Reviews
Volume46
Issue number14
DOIs
StatePublished - 21 Jul 2017

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