Transdermal thiol-acrylate polyethylene glycol hydrogel synthesis using near infrared light

Solchan Chung, Hwangjae Lee, Hyung Seok Kim, Min Gon Kim, Luke P. Lee, Jae Young Lee

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Light-induced polymerization has been widely applied for hydrogel synthesis, which conventionally involves the use of ultraviolet or visible light to activate a photoinitiator for polymerization. However, with these light sources, transdermal gelation is not efficient and feasible due to their substantial interactions with biological systems, and thus a high power is required. In this study, we used biocompatible and tissue-penetrating near infrared (NIR) light to remotely trigger a thiol-acrylate reaction for efficient in vivo gelation with good controllability. Our gelation system includes gold nanorods as a photothermal agent, a thermal initiator, diacrylate polyethylene glycol (PEG), and thiolated PEG. Irradiation with a low-power NIR laser (0.3 W cm-2) could induce gelation via a mixed-mode reaction with a small increase in temperature (∼5 °C) under the optimized conditions. We also achieved successful transdermal gelation via the NIR-assisted photothermal thiol-acryl reactions. This new type of NIR-assisted thiol-acrylate polymerization provides new opportunities for in situ hydrogel formation for injectable hydrogels and delivery of drugs/cells for various biomedical applications.

Original languageEnglish
Pages (from-to)14213-14221
Number of pages9
JournalNanoscale
Volume8
Issue number29
DOIs
StatePublished - 7 Aug 2016

Bibliographical note

Publisher Copyright:
© 2016 The Royal Society of Chemistry.

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