Trans-regulation of syndecan functions by hetero-oligomerization

Youngsil Choi; Mi Jung Kwon; Yangmi Lim; Ji Hye Yun; Weontae Lee; Eok Soo Oh

doi:10.1074/jbc.M114.611798

Trans-regulation of syndecan functions by hetero-oligomerization

Youngsil Choi, Mi Jung Kwon, Yangmi Lim, Ji Hye Yun, Weontae Lee, Eok Soo Oh

Department of Life Science

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Background: Syndecans form non-covalently linked homodimers through their highly conserved transmembrane domains. Results: Syndecan-2 and -4 exhibit heteromolecular interaction, and this interaction regulates syndecan-mediated cellular functions. Conclusion: Hetero-oligomerization produces distinct syndecan functions. Significance: Our finding offers new insights into the underlying signaling mechanisms of syndecans.

Original language	English
Pages (from-to)	16943-16953
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	290
Issue number	27
DOIs	https://doi.org/10.1074/jbc.M114.611798
State	Published - 3 Jul 2015

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

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abstract = "Background: Syndecans form non-covalently linked homodimers through their highly conserved transmembrane domains. Results: Syndecan-2 and -4 exhibit heteromolecular interaction, and this interaction regulates syndecan-mediated cellular functions. Conclusion: Hetero-oligomerization produces distinct syndecan functions. Significance: Our finding offers new insights into the underlying signaling mechanisms of syndecans.",

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AU - Lim, Yangmi

AU - Yun, Ji Hye

AU - Lee, Weontae

AU - Oh, Eok Soo

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Y1 - 2015/7/3

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AB - Background: Syndecans form non-covalently linked homodimers through their highly conserved transmembrane domains. Results: Syndecan-2 and -4 exhibit heteromolecular interaction, and this interaction regulates syndecan-mediated cellular functions. Conclusion: Hetero-oligomerization produces distinct syndecan functions. Significance: Our finding offers new insights into the underlying signaling mechanisms of syndecans.

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Trans-regulation of syndecan functions by hetero-oligomerization

Abstract

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