Trans-regulation of syndecan functions by hetero-oligomerization

Youngsil Choi, Mi Jung Kwon, Yangmi Lim, Ji Hye Yun, Weontae Lee, Eok Soo Oh

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Background: Syndecans form non-covalently linked homodimers through their highly conserved transmembrane domains. Results: Syndecan-2 and -4 exhibit heteromolecular interaction, and this interaction regulates syndecan-mediated cellular functions. Conclusion: Hetero-oligomerization produces distinct syndecan functions. Significance: Our finding offers new insights into the underlying signaling mechanisms of syndecans.

Original languageEnglish
Pages (from-to)16943-16953
Number of pages11
JournalJournal of Biological Chemistry
Issue number27
StatePublished - 3 Jul 2015

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.


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