TRAF1 and its biological functions

Soo Young Lee, Yongwon Choi

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

45 Scopus citations

Abstract

Tumor necrosis factor (TNF) receptor-associated factor (TRAF)1 was originally identified based on its ability to interact with the cytosolic domain of TNF receptor type 2 (TNFR2). TRAF1 is unique among TRAF proteins in that it lacks RING domain found in the N-terminal regions of other TRAFs. TRAF1 can associate with multiple TNFR family members and can also bind several protein kinases and adaptor proteins suggesting that this protein likely possesses multiple functions in cytokine signaling networks. Although our understanding of TRAF1 functions and the underlying mechanisms at molecular and cellular levels has been advanced in recent years, much still needs to be learned before we have a full grasp of TRAF1 biology.

Original languageEnglish
Title of host publicationTNF Receptor Associated Factors (TRAFs)
PublisherSpringer New York
Pages25-31
Number of pages7
ISBN (Print)9780387706290
DOIs
StatePublished - 2007

Publication series

NameAdvances in Experimental Medicine and Biology
Volume597
ISSN (Print)0065-2598

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