TY - JOUR
T1 - Toxicity bioassay in Sprague-Dawley rats exposed to 20 kHz triangular magnetic field for 90 days
AU - Kim, Sung Ho
AU - Lee, Hae June
AU - Choi, Soo Yong
AU - Gimm, Youn Myoung
AU - Pack, Jeong Ki
AU - Choi, Hyung Do
AU - Lee, Yun Sil
PY - 2006/2
Y1 - 2006/2
N2 - Sprague-Dawley rats (10 each of male and female per group for sham and magnetic field exposed) were exposed in a carrousel irradiator to 20 kHz intermediate frequency (IF) magnetic field at 6.25 μT rms for 8 h/day, 5 days/week for 90 days. Urine analysis (pH, serum glucose, protein, ketone bodies, RBC, WBC, bilirubin, urobilinogen, and specific gravity), blood analysis [WBC, RBC, hemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), thrombocyte count, and leucocyte count], blood biochemistry (total protein, blood urea nitrogen, creatinine, glucose, total bilirubin, total cholesterol, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and lactate dehydrogenase), and histopathological analysis for organs such as liver, kidney, testis, ovary, spleen, brain, heart, and lung were performed on day 90. Results showed no significant differences in the above analyses between IF magnetic field exposed and sham control rats. Therefore, we conclude that there were no significant toxicities in rats exposed to 20 kHz IF triangular magnetic field-exposure for 90 days.
AB - Sprague-Dawley rats (10 each of male and female per group for sham and magnetic field exposed) were exposed in a carrousel irradiator to 20 kHz intermediate frequency (IF) magnetic field at 6.25 μT rms for 8 h/day, 5 days/week for 90 days. Urine analysis (pH, serum glucose, protein, ketone bodies, RBC, WBC, bilirubin, urobilinogen, and specific gravity), blood analysis [WBC, RBC, hemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), thrombocyte count, and leucocyte count], blood biochemistry (total protein, blood urea nitrogen, creatinine, glucose, total bilirubin, total cholesterol, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and lactate dehydrogenase), and histopathological analysis for organs such as liver, kidney, testis, ovary, spleen, brain, heart, and lung were performed on day 90. Results showed no significant differences in the above analyses between IF magnetic field exposed and sham control rats. Therefore, we conclude that there were no significant toxicities in rats exposed to 20 kHz IF triangular magnetic field-exposure for 90 days.
KW - Blood analysis
KW - Histological analysis
KW - Intermediate frequency
KW - Serology
KW - Serum biochemistry
KW - Urine analysis
UR - http://www.scopus.com/inward/record.url?scp=33644864303&partnerID=8YFLogxK
U2 - 10.1002/bem.20182
DO - 10.1002/bem.20182
M3 - Article
C2 - 16283665
AN - SCOPUS:33644864303
SN - 0197-8462
VL - 27
SP - 105
EP - 111
JO - Bioelectromagnetics
JF - Bioelectromagnetics
IS - 2
ER -